放射性肺损伤相关细胞因子及防治的研究进展

doi:10.11904/j.issn.1002-3070.2015.03.013

Abstract

Abstract:

Radiation therapy is one of the main therapeutic means of thoracic malignant tumors.When received certain radiation,lung may cause the common complication of chest tumor radiotherapy-Radiation-induced Lung Injury(RILI),which restricts the radiation dose for the tumor region and may affect patient outcomes.RILI is closely associated with multiple cytokines,such as interleukin family,tumor necrosis factor,transforming growth factor,etc.Currently,research on RILI control Methods has also made some breakthrough,this article elaborates on this individually.

Key words: Radiation-induced lung injury, Cytokines, Cytokine inhibitors, Gene therapy, Stem cell therapy

CLC Number:

R734.2

XING Qi,ZHANG Qian,QIAO Wenbo. Research advances on cytokines and prevention in radiation induced lung injury[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 250-253.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2015.03.013

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2015/V29/I3/250

References

1 Benveniste M,Welsh J,Godoy M,et al.New era of radiotherapy:An update in radiation-induced lung disease[J].Clinical Radiology,2013,68(6):275-290.
2 蒋恒,杨伟志.细胞因子与放射性肺损伤[J].中华放射肿瘤学杂志,2006,15(6):512-515.
3 马晓薇.牛磺酸及血管紧张素转化酶抑制剂对大鼠急性肺损伤的保护作用研究[D].重庆:重庆医科大学,2013:21-24.
4 张小静.放射性肺损伤研究进展[D].重庆:重庆医科大学,2013:6-11.
5 刘莉,张米娜.放射性肺炎及肺纤维化[J].临床内科杂志,2011,28(4):227-229.
6 Chung E,Hudak K,Horton J,et al.Transforming growth factor alpha is a critical mediator of radiation lung injury[J].Radiat Res,2014,182(3):350-362.
7 Madani I,De Ruyck K,Goeminne H,et al.Predicting risk of radiation-induced lung injury[J].J Thorac Oncol,2007,2(9):864-874.
8 崔莹,吕达,乔文波.IL-6、IL-8和IL-10与放射性肺损伤相关性研究[J].实用肿瘤学杂志,2014,28(3):202-206.
9 Takai E,Tsukimoto M,Kojima S.TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells,which is involved in fibrotic response to TGF-β1[J].PLoS One,2013,8(10):e76346.
10 孙文铸.IGF-Ⅰ和TGF-β1在肺纤维化形成中的作用及辛伐他汀对其干预效应研究作者[D].吉林:吉林大学,2007:2-10.
11 Hung C,Rohani M,Lee S,et al.Role of IGF-1 pathway in lung fibroblast activation[J].Respir Res,2013,14(1):102-112.
12 Shi Y,Dong Y,Duan Y,et al.Substrate stiffness influences TGF-beta1-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling[J].Mol Med Rep,2013,7(2):419-424.
13 Zhang S,Danchuk S,Bonvillain R,et al.Interleukin 6 mediates the therapeutic effects of adipose-derived stromal/stem cells in lipopolysaccharide-induced acute lung injury[J].Stem Cells,2014,32(6):1616-1628.
14 Kuhlmann U,Chwieralski C,Reinhold D,et al.Radiation-induced matrix production of lung fibroblasts is regulated by interleukin-8[J].Int J Radiat Biol,2009,85(2):138-143.
15 Hagio T,Matsumoto S,Nakao S,et al.Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters[J].Eur J Pharmacol,2004,488(1-3):173-180.
16 Rube C,Wilfert F,Palm J,et al.Irradiation induces a biphasic expression of proinflammatory cytokines in the lung[J].Strahlenther Onkol,2004,180(7):442-448.
17 Sturrock A,Vollbrecht T,Mir-Kasimov M,et al.Mechanisms of suppression of alveolar epithelial cell GM-CSF expression in the setting of hyperoxic stress[J].Am J Physiol Lung Cell Mol Physiol,2010,298(3):446-453.
18 吕国庆,吴恒,张雨洁.Ⅱ、Ⅲ期乳腺癌术后三种放疗方式对肺损伤的研究[J].吉林医学,2010,31(27):4661-4662.
19 Vogelius I,Westerly D,Aznar M,et al.Estimated radiation pneumonitis risk after photon versus proton therapy alone or combined with chemotherapy for lung cancer[J].Acta Oncol,2011,50(6):772-776.
20 张燕,王晓萍.放射性肺损伤的预防和治疗进展[J].临床肺科杂志,2012,(3):526-527.
21 Epperly M,Guo H,Jefferson M,et al.Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase-plasmid/ liposomes(MnSOD-PL)during lung radioprotective gene therapy[J].Gene Ther,2003,10(2):163-171.
22 Molteni A,Moulder J,Cohen E,et al.Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker[J].Int J Radiat Biol,2000,76(4):523-532.
23 Mahmood J,Jelveh S,Zaidi A,et al.Renin-angiotensin system combined with an antioxidant is highly effective in mitigating radiation-induced lung damage[J].Int J Radiat Oncol Biol Phys,2014,89(4):722-728.
24 Ogata T,Yamazaki H,Teshima T,et al.Anti-IL-6 receptor antibody does not ameliorate radiation pneumonia in mice[J].Exp Ther Med,2012,4(2):273-276.
25 Zhang M,Qian J,Xing X,et al.Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung[J].Clin Cancer Res,2008,14(6):1868-1876.
26 Wang J,Xu H,Li B,et al.Preliminary study of protective effects of flavonoids against radiation-induced lung injury in mice[J].Asian Pac J Cancer Prev,2012,13(12):6441-6446.
27 Devaney J,Contreras M,Laffey J.Clinical rview:gene-based therapies for ALI/ARDS:where are we now？[J].Crit Care,2011,15(3):224-236.
28 吕达,乔文波.放射性肺损伤预测因子与治疗进展[J].实用肿瘤学杂志,2013,27(6):554-558.
29 戴夕超,杜秀平,张西志,等.双氢青蒿素对早期放射性肺损伤大鼠TNF-α表达的影响[J].中华肿瘤防治杂志,2010,17(10):728-733.
30 Przybyszewska M,Mioszewska J,Rzońca S,et al.Soluble TNF-α receptor I encoded on plasmid vector and its application in experimental gene therapy of radiation-induced lung fibrosis[J].Arch Immunol Ther Exp(Warsz),2011,59(4):315-326.

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Research advances on cytokines and prevention in radiation induced lung injury

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