恶性肿瘤来源外泌体在巨噬细胞M2极化中作用的研究进展

doi:10.11904/j.issn.1002-3070.2022.01.011

Abstract

Abstract: Exosomes are nanometer(30~150 nm)membrane-bound vesicles,which contain a variety of bioactive substances,such as lipids,proteins,mRNA,and non-coding RNA,which can be secreted by almost all cells under normal and pathological conditions.Many studies have found that tumor cells can deliver bioactive molecules such as nucleic acid and proteins to recipient cells by secreting exosomes,changing the phenotype or function of recipient cells,and further changing the tumor microenvironment to affect tumor progression.Based on the research progress,this article briefly introduces the role of tumor exosomes in changing the phenotype of macrophage.

Key words: Exosome, M2 type macrophages, Tumor

CLC Number:

R730.2

SHI Jingtong, CHEN Minjie, SUN Yihua. Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages[J]. Journal of Practical Oncology, 2022, 36(1): 59-63.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.01.011

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I1/59

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Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages

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