卵巢癌对富脂大网膜的器官趋向性转移的研究进展

doi:10.11904/j.issn.1002-3070.2022.01.010

Abstract

Abstract: Tumor metastasis is a complex multi-step process involving the interaction between tumor cells and various matrix components in the tumor microenvironment.Ovarian cancer is the deadliest gynecological malignancy,characterized by disseminated peritoneal metastasis.There is evidence that ovarian cancer has a specific metastatic tendency to the fat-rich omentum.The omentum plays a key role in this process.It forms a metastatic tumor microenvironment in the abdominal cavity to promote ovarian cancer metastasis.Taking into account the unique biological characteristics of ovarian cancer metastasis,the elucidation molecular mechanism of the interaction between ovarian cancer cells and surrounding stromal cells in the fat-rich metastatic microenvironment will provide further insights into new treatment methods for patients with advanced ovarian cancer.Here,this article reviews the interaction mechanism between ovarian cancer cells and various stromal cells in the metastatic tumor microenvironment,and clarifys how fat-rich omentum tumor microenvironment contributes to the occurrence and development of ovarian cancer metastasis.

Key words: Ovarian cancer, Omentum, Metastasis, Tumor microenvironment

CLC Number:

R737.31

DONG Lina, LIANG Tian, ZHANG Xian, ZHANG Guangmei. Research progress on tropism of ovarian cancer to fat-rich omentum organs[J]. Journal of Practical Oncology, 2022, 36(1): 54-58.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.01.010

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I1/54

References

1 Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.
2 Kuroki L,Guntupalli SR.Treatment of epithelial ovarian cancer[J].BMJ,2020,371:3773.
3 Mills K,Fuh K.Recent advances in understanding,diagnosing,and treating ovarian cancer[J].F1000Res,2017,6:84.
4 Wang Y,Zhao G,Condello S,et al.Frizzled-7 identifies platinum tolerant ovarian cancer cells susceptible to ferroptosis[J].Cancer Res,2021,81(2):384-399.
5 Zhang S,Iyer S,Ran H,et al.Genetically defined,syngeneic organoid platform for developing combination therapies for ovarian cancer[J].Cancer Discov,2021,11(2):362-383.
6 Motohara T,Masuda K,Morotti M,et al.An evolving story of the metastatic voyage of ovarian cancer cells:cellular and molecular orchestration of the adipose-rich metastatic microenvironment[J].Oncogene,2019,38(16):2885-2898.
7 Nieman KM,Kenny HA,Penicka CV,et al.Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth[J].Nat Med,2011,17(11):1498-1503.
8 Schild T,Low V,Blenis J,et al.Unique metabolic adaptations dictate distal organ-specific metastatic colonization[J].Cancer Cell,2018,33(3):347-354.
9 Chkourko Gusky H,Diedrich J,MacDougald OA,et al.Omentum and bone marrow:how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression[J].Obes Rev,2016,17(11):1015-1029.
10 Worzfeld T,Pogge von Strandmann E,Huber M,et al.The unique molecular and cellular microenvironment of ovarian cancer[J].Front Oncol,2017,7:24.
11 de Groot AE,Roy S,Brown JS,et al.Revisiting seed and soil:examining the primary tumor and cancer cell foraging in metastasis[J].Mol Cancer Res,2017,15(4):361-370.
12 Jiménez-Sánchez A,Cybulska P,Mager KL,et al.Unraveling tumor-immune heterogeneity in advanced ovarian cancer uncovers immunogenic effect of chemotherapy[J].Nat Genet,2020,52(6):582-593.
13 Natarajan S,Foreman KM,Soriano MI,et al.Collagen remodeling in the hypoxic tumor-mesothelial niche promotes ovarian cancer metastasis[J].Cancer Res,2019,79(9):2271-2284.
14 Pearce OMT,Delaine-Smith RM,Maniati E,et al.Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers[J].Cancer Discov,2018,8(3):304-319.
15 Kalluri R.The biology and function of fibroblasts in cancer[J].Nat Rev Cancer,2016,16(9):582-598.
16 Jeon ES,Moon HJ,Lee MJ,et al.Cancer-derived lysophosphatidic acid stimulates differentiation of human mesenchymal stem cells to myofibroblast-like cells[J].Stem Cells,2008,26(3):789-797.
17 Mitra AK,Zillhardt M,Hua Y,et al.MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer[J].Cancer Discov,2012,2(12):1100-1108.
18 Meza-Perez S,Randall TD.Immunological functions of the omentum[J].Trends Immunol,2017,38(7):526-536.
19 Krishnan V,Clark R,Chekmareva M,et al.In vivo and ex vivo approaches to study ovarian cancer metastatic colonization of milky spot structures in peritoneal adipose[J].J Vis Exp,2015,(105):e52721.
20 Clark R,Krishnan V,Schoof M,et al.Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models[J].Am J Pathol,2013,183(2):576-591.
21 Aras S,Zaidi MR.TAMeless traitors:macrophages in cancer progression and metastasis[J].Br J Cancer,2017,117(11):1583-1591.
22 Pollard JW.Tumour-educated macrophages promote tumour progression and metastasis[J].Nat Rev Cancer,2004,4(1):71-78.
23 Duluc D,Delneste Y,Tan F,et al.Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells[J].Blood,2007,110(13):4319-4330.
24 Romero IL,Mukherjee A,Kenny HA,et al.Molecular pathways:trafficking of metabolic resources in the tumor microenvironment[J].Clin Cancer Res,2015,21(4):680-686.
25 Iyengar P,Espina V,Williams TW,et al.Adipocyte-derived collagen VI affects early mammary tumor progression in vivo,demonstrating a critical interaction in the tumor/stroma microenvironment[J].J Clin Invest,2005,115(5):1163-1176.
26 Suh DH,Kim HS,Kim B,et al.Metabolic orchestration between cancer cells and tumor microenvironment as a coevolutionary source of chemoresistance in ovarian cancer:a therapeutic implication[J].Biochem Pharmacol,2014,92(1):43-54.
27 Nieman KM,Romero IL,Van Houten B,et al.Adipose tissue and adipocytes support tumorigenesis and metastasis[J].Biochim Biophys Acta,2013,1831(10):1533-1541.
28 Nieman KM,Kenny HA,Penicka CV,et al.Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth[J].Nat Med,2011,17(11):1498-1503.
29 Guaita-Esteruelas S,Gumà J,Masana L,et al.The peritumoural adipose tissue microenvironment and cancer.The roles of fatty acid binding protein 4 and fatty acid binding protein 5[J].Mol Cell Endocrinol,2018,462(Pt B):107-118.
30 Mukherjee A,Chiang CY,Daifotis HA,et al.Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance[J].Cancer Res,2020,80(8):1748-1761.
31 Harjes U,Bridges E,Gharpure KM,et al.Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4[J].Oncogene,2017,36(7):912-921.
32 Zhou J,Alfraidi A,Zhang S,et al.A novel compound ARN-3236 inhibits salt-inducible kinase 2 and sensitizes ovarian cancer cell lines and xenografts to paclitaxel[J].Clin Cancer Res,2017,23(8):1945-1954.
33 Zhao J,Zhang X,Gao T,et al.SIK2 enhances synthesis of fatty acid and cholesterol in ovarian cancer cells and tumor growth through PI3K/Akt signaling pathway[J].Cell Death Dis,2020,11(1):25.
34 Miranda F,Mannion D,Liu S,et al.Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche[J].Cancer Cell,2016,30(2):273-289.
35 Cymbaluk-Płoska A,Gargulińska P,Chudecka-Głaz A,et al.The suitability of FGF21 and FGF23 as new biomarkers in endometrial cancer patients[J].Diagnostics(Basel),2020,10(6):414.
36 Wesche J,Haglund K,Haugsten EM.Fibroblast growth factors and their receptors in cancer[J].Biochem J,2011,437(2):199-213.
37 Li JR,Chiu KY,Ou YC,et al.Alteration in serum concentrations of FGF19,FGF21,and FGF23 in patients with urothelial carcinoma[J].Biofactors,2019,45(1):62-68.
38 Owen BM,Mangelsdorf DJ,Kliewer SA.Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21[J].Trends Endocrinol Metab,2015,26(1):22-29.
39 Huang X,Yu C,Jin C,et al.Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis[J].Mol Carcinog,2006,45(12):934-942.
40 Akyol M,Alacacioglu A,Demir L,et al.The alterations of serum FGF-21 levels,metabolic and body composition in early breast cancer patients receiving adjuvant endocrine therapy[J].Cancer Biomark,2017,18(4):441-449.

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Research progress on tropism of ovarian cancer to fat-rich omentum organs

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