Abstract: Objective To investigate the clinicopathologic features of gastric cancer with peritoneal dissemination,and also to evaluate the impact of different operations on the prognosis.Methods A statistical analysis was performed retrospectively with regard to clinicopathologic features and survival of 91 cases of gastric cancer with peritoneal dissemination.Results Univariate analysis revealed that tumor size,tumor location,degree of differentiation,Borrmann types,organ infiltration,lymph node metastasis,depth of invasion and hepatic metastasis were correlated with Peritoneal dissemination(P＜0.05).The Logistic regression model revealed that the depth of invasion and organ infiltration were independent factors(P＜0.05).The difference of age,ascites and organ infiltration between the non-radical resection and palliative operation groups was statistically significant(P＜0.05).The different survival time of palliative operation group with feeding neostomy,gastrointestinal anastomosis and exploratory laparotomy was not statistically significant(P＞0.05).The median survival time in non-radical resection group was 13.4 months and in palliative operation group was 4.2 months.The difference was statistically significant(P＜0.01).Multivariate analysis by Cox regression indicated that the type of operation and tumor size were significant factors affecting the prognosis of the patients with peritoneal dissemination.Conclusions The clinicopathologic features of patients with gastric cancer are intimately correlated with peritoneal dissemination.Non-radical resection can improve the prognosis of peritoneal dissemination patients of gastric cancer.