PELP1表达与胃癌演进及预后相关性分析

doi:10.11904/j.issn.1002-3070.2022.01.006

Abstract

Abstract: Objective The aim of this study was to investigate the relationship and significance of proline,glutamate and leucine rich protein 1(PELP1)in the progression and prognosis of gastric cancer.Methods Immunohistochemistry was used to detect the expression of PELP1 protein in 39 normal gastric tissues,48 low-grade atypical hyperplasia gastric tissues,28 high-grade atypical hyperplasia gastric tissues,and 77 gastric cancer tissues.The expression of PELP1 in different stages of gastric cancer was observed.The correlation between the level of PELP1 and clinicopathological parameters of gastric cancer was analyzed.Kaplan-Meier Plotter,an online cancer survival analysis tool,was used to analyze the relationship between PELP1 expression in gastric cancer and overall survival(OS),survival before first progression(FP)and post progression survival(PPS).Results The level of PELP1 increased gradually during the progression of gastric cancer,and the differences were significant(P＜ 0.05);The expression of PELP1 in gastric cancer was significantly correlated with lymph node metastasis,low tumor differentiation and high clinical stage(P＜ 0.05);The OS,FP and PPS of patients with high level of PELP1 were significantly shorter than those with low level of PELP1(P ＜ 0.05).Conclusion The high expression of PELP1 is involved in the progression of gastric cancer and suggests a poor prognosis for patients.

Key words: Gastric Cancer, Proline,glutamic and leucine rich protein 1, Immunohistochemistry, Survival analysis

CLC Number:

R735.2

ZHAO Baoshan, LIANG Guanying, XU Shengjie, QIAO Hui, CHEN Hongxia, MA Ying, JU Xueping, WANG Lin. Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis[J]. Journal of Practical Oncology, 2022, 36(1): 31-36.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.01.006

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I1/31

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Analysis of the correlation between PELP1 expression and gastric cancer progression and prognosis

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