放射性肺损伤相关细胞因子及防治的研究进展

doi:10.11904/j.issn.1002-3070.2015.03.013

实用肿瘤学杂志 ›› 2015, Vol. 29 ›› Issue (3): 250-253.doi: 10.11904/j.issn.1002-3070.2015.03.013

放射性肺损伤相关细胞因子及防治的研究进展

邢琦, 张倩综述, 乔文波审校

哈尔滨医科大学附属肿瘤医院(哈尔滨 150081)

收稿日期:2014-11-17 出版日期:2015-06-28 发布日期:2015-06-25
通讯作者: 乔文波 E-mail:wenboq@163.com
作者简介:邢琦,女,(1988-),硕士研究生,从事肿瘤放射治疗的研究
基金资助:
黑龙江省教育厅科学技术研究项目(11531194)

Research advances on cytokines and prevention in radiation induced lung injury

XING Qi,ZHANG Qian,QIAO Wenbo

Department of Radiotherapy,The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081,China

Received:2014-11-17 Online:2015-06-28 Published:2015-06-25

摘要/Abstract

摘要：

放射治疗是胸部恶性肿瘤治疗的主要手段之一,在放疗期间肺部正常组织接受一定辐射后会导致胸部肿瘤放疗中常见的并发症——放射性肺损伤(Radiation-induced lung injury,RILI),其制约了肿瘤区域的放疗剂量,影响患者治疗效果。研究发现RILI发病机制与多种细胞因子相关,如白介素家族、肿瘤坏死因子和转化生长因子等,目前对RILI防治手段的探索也有了一定突破,本文将逐一对此进行阐述。

关键词: 放射性肺损伤, 细胞因子, 细胞因子抑制剂, 基因治疗, 干细胞治疗

Abstract:

Radiation therapy is one of the main therapeutic means of thoracic malignant tumors.When received certain radiation,lung may cause the common complication of chest tumor radiotherapy-Radiation-induced Lung Injury(RILI),which restricts the radiation dose for the tumor region and may affect patient outcomes.RILI is closely associated with multiple cytokines,such as interleukin family,tumor necrosis factor,transforming growth factor,etc.Currently,research on RILI control Methods has also made some breakthrough,this article elaborates on this individually.

Key words: Radiation-induced lung injury, Cytokines, Cytokine inhibitors, Gene therapy, Stem cell therapy

中图分类号:

R734.2

邢琦, 张倩综述, 乔文波审校. 放射性肺损伤相关细胞因子及防治的研究进展[J]. 实用肿瘤学杂志, 2015, 29(3): 250-253.

XING Qi,ZHANG Qian,QIAO Wenbo. Research advances on cytokines and prevention in radiation induced lung injury[J]. PRACTICAL ONCOLOGY JOURNAL, 2015, 29(3): 250-253.

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放射性肺损伤相关细胞因子及防治的研究进展

Research advances on cytokines and prevention in radiation induced lung injury

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