似果蝇粒状头样2基因与肿瘤关系的研究进展

doi:10.11904/j.issn.1002-3070.2017.03.013

摘要/Abstract

摘要： 似果蝇粒状头样2基因(Grainyhead-like 2,GRHL2)是果蝇粒状头样基因在哺乳动物中的同源基因之一,是哺乳动物所具有的一种似果蝇粒状头样转录因子。在正常机体中,GRHL2参与调控上皮细胞的分化与发育,而对于肿瘤,GRHL2的作用是复杂的,既可抑制肿瘤的发生,也可以促进肿瘤的形成,特别是上皮来源的恶性肿瘤大部分都涉及上皮-间质转化(Epithelial-mesenchymal transition,EMT)过程。进一步研究GRHL2与肿瘤的关系,将为肿瘤患者的临床诊治带来新的思路,本文就GRHL2与肿瘤的关系进行综述。

关键词: 似果蝇粒状头样2基因, 肿瘤, 上皮-间质转化

Abstract: Grainhead-like 2(GRHL2)is one of the homologous genes of Drosophila granule head-like gene in mammals,which is a kind of Drosophila granule head transcription factor.In normal organisms,GRHL2 is involved in the regulation of epithelial cell differentiation and development.In tumors,GRHL2 is complex.GRHL2 not only inhibits tumorigenesis,but it also promotes tumor formation,especially epithelial origin of malignant tumors mostly involving epithelial-mesenchymal transition(EMT)process.Further study of the relationship between GRHL2 and tumor will provide a new idea for the clinical diagnosis and treatment of cancer patients.The relationship between GRHL2 and tumor is reviewed in this paper.

Key words: Grainyhead-like 2, Neoplasm, Epithelial-mesenchymal transition

中图分类号:

魏明莉，曾军综述，黄娜审校. 似果蝇粒状头样2基因与肿瘤关系的研究进展[J]. 实用肿瘤学杂志, 2017, 31(3): 254-257.

WEI Mingli,ZENG Jun,HUANG Na. Research progress of the relationship between granule head-like 2 gene and tumor in Drosophila melanogaster[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(3): 254-257.

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