ICAM-1在肿瘤中的研究进展

doi:10.11904/j.issn.1002-3070.2018.01.016

摘要/Abstract

摘要： 细胞间黏附分子(Intercellular adhesion molecule-1,ICAM-1)又称CD54,是免疫球蛋白超家族的一种跨膜糖蛋白,参与肿瘤细胞免疫调节、血管生成、侵袭和远处转移。国内外诸多研究证明ICAM-1在多种恶性肿瘤中异常高表达,促进了肿瘤的发生、发展并影响其预后,同时对预测个别肿瘤放化疗敏感性有一定的作用。因此ICAM-1可能为恶性肿瘤的诊断和治疗提供参考依据。本文就近年来ICAM-1在恶性肿瘤中的研究做一综述。

关键词: ICAM-1, 肿瘤, 进展, 预后

Abstract: Intercellular adhesion molecule(ICAM-1),also known as CD54,is a transmembrane glycoprotein of the immunoglobulin superfamily and involved in tumor cell immune regulation,angiogenesis,invasion and distant metastasis.Many studies from domestic and abroad have proved that ICAM-1 is highly expressed in a variety of malignant tumors,which promotes the occurrence,development and prognosis of tumor.ICAM-1 also plays an important role in predicting the chemosensitivity of individual tumors.Therefore,ICAM-1 may provide a reference for the diagnosis and treatment of malignant tumors.This article summarizes effects of ICAM-1 on malignant tumors in recent years.

Key words: ICAM-1, Tumor, Progress, Prognosis

中图分类号:

庄敏敏, 张云艳. ICAM-1在肿瘤中的研究进展[J]. 实用肿瘤学杂志, 2018, 32(1): 82-86.

ZHUANG Minmin, ZHANG Yunyan. Research progress of intercellular adhesion molecule-1 in tumor[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 82-86.

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