Caveolin-1的表达与EGFR突变在NSCLC中的相关性及其临床意义的研究

doi:10.11904/j.issn.1002-3070.2014.06.004

Abstract

Abstract:

Objective This study aims to examine expression of Caveolin-1 in non smoking cell lung cancer(NSCLC)and to discusses the relationship between expression of Caveolin-1 and the Epidermal growth factor receptor mutations.Methods Immunohistochemical staining was used to determine the Caveolin-1 expression and ARMS-qPCR was used to measure EGFR mutations in 40 cases of lung cancer tissue.The clinical pathological characteristics and correlations in patients were analyzed.Results The expression of Caveolin-1 in human lung cancer was significantly lower than that in normal lung tissue,and negatively correlated with EGFR mutations,which was statistically significant.Conclusion Caveolin-1 expression is negatively correlated with EGFR mutations in non-small cell lung cancer and related to the histologic type.Caveolin-1 may be a molecular target for diagnosis and judgment of NSCLC.

Key words: Caveolin-1, EGFR mutation, Non-small cell lung carcinoma, Immunohistochemical

CLC Number:

R734.2

XU Ruirui,WEN Liyuan,SUN Guoqiang,MENG Qingwei,SUN Lichun,CAI Li. Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance[J]. PRACTICAL ONCOLOGY JOURNAL, 2014, 28(6): 498-502.

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Research on the expression of Caveolin-1 with EGFR mutations in non-small cell lung cancer tissues and its clinical significance

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