鞣花酸及其肠道代谢产物在大肠癌中的研究进展

doi:10.11904/j.issn.1002-3070.2016.03.014

Abstract

Abstract: Colorectal cancer is a common gastrointestinal malignant disease.Its incidence and mortality rates are elevated.In recent years,chemical plant extracts has attracted considerable attention in the chemical prevention and treatment of colorectal cancer.Studies found that ellagic acid and its gut microbiota metabolite have the effect on colorectal cancer.The mechanisms are closely related to promoting tumor cell apoptosis and inhibiting tumor cell proliferation,blocking the cell cycle,inhibiting tumor angiogenesis,reversing resistance and enhancing the sensitivity of chemotherapy drug.In this paper,the latest research progress and the mechanisms of the ellagic acid and its gut microbiota metabolite on the prevention and treatment of colorectal cancer are reviewed.

Key words: Ellagic acid, Gut microbiota metabolite, Colorectal cancer

CLC Number:

R735.3

ZHANG Jinning,LI Guodong,CHEN Hongsheng,LIU Ming. Research progress of the effect and mechanisms of ellagic acid and its gut microbiota metabolite on colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(3): 262-265.

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Research progress of the effect and mechanisms of ellagic acid and its gut microbiota metabolite on colorectal cancer

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