结直肠癌肿瘤微环境中调节性T细胞CD39、CD73亚群及二者双阳性亚群的临床意义

doi:10.11904/j.issn.1002-3070.2017.04.008

Abstract

Abstract: Objective The objectives of this study were to investigate the clinical significance of CD39,CD73,double positive subgroups for CD39 and CD73,and other lymphocytes with clinicopathological parameters in the microenvironment of colorectal cancer.Methods Tumor infiltrating lymphocyte(TIL)was collected from 24 patients with colorectal cancer after radical resection.The expression of CD39⁺,CD73⁺ or CD39⁺ with CD73⁺ in T cells were measured by flow cytometry.The association between these subgroups and clinicopathologic parameters was analyzed.Results The CD73⁺ and CD39⁺ with CD73⁺ subgroups were associated with lymph node metastasis and poor degree of differentiation,and this mechanism was closely related to tumor-associated inflammation.Conclusion CD39⁺ with CD73⁺ colorectal tumor infiltration Treg has a more unique biological activity than other Treg group.This study provides a new idea and theoretical basis for predicting the prognosis of colorectal cancer.

Key words: Colon cancer, Tumor-infiltrating lymphocyte, Regulatory T lymphocyte , CD39, CD73

CLC Number:

R574.62

WANG Dongliang ,QI Ning ,MU Guannan ,ZHANG Yuegui. Clinical significance of CD39 CD73 subsets and both of them positive subgroups of regulatory T cells in the microenvironment of colorectal cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(4): 329-334.

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Clinical significance of CD39 CD73 subsets and both of them positive subgroups of regulatory T cells in the microenvironment of colorectal cancer

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