Krüpple样转录因子4与结肠癌发生发展关系的研究进展

doi:10.11904/j.issn.1002-3070.2020.05.013

Abstract

Abstract: Krüpple-like factor 4(KLF4),as a member of the zinc finger transcription factor family,has regulatory effects on the develcopment,metastasis,and drug resistance of colon cancer.KLF4 plays a role in suppressing or promoting colon cancer through epithelial mesenchymal transformation(EMT),tumor stem cells(CSCs),and multiple signaling pathways.This article reviews the latest research progress on the mechanism of KLF4 and colon cancer,which is of great significance for the identification of colon cancer treatment targets and the clarification of its molecular mechanism.

Key words: Krüpple-like transcription factor 4, Colon cancer, Molecular mechanism

CLC Number:

R735.3+5

ZHANG Mengzhe, KANG Xiangdong. Research progress on the relationship between Krüpple-like transcription factor 4 and the development of colorectal cancer[J]. Journal of Practical Oncology, 2020, 34(5): 456-459.

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http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I5/456

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Research progress on the relationship between Krüpple-like transcription factor 4 and the development of colorectal cancer

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