植物化学物在癌症化学预防中的作用

doi:10.11904/j.issn.1002-3070.2020.05.014

Abstract

Abstract: Cancer is one of the main causes of death in China and around the world.Its etiology has not been fully understood,but its prevention and treatment has always been a hot field.Although various cancer therapies can improve the quality of life and survival of cancer patients,once the cancer has metastasized,it is difficult for patients to cure.Therefore,the prevention of cancer is particularly important.A large number of studies have shown that phytochemicals from fruits,vegetables and grains have a preventive effect on a variety of cancers.Thus,this article will review the role and possible mechanisms of major naturally occurring phytochemicals in cancer chemoprevention.

Key words: Cancer, Phytochemicals, Chemoprevention

CLC Number:

R282.71

GUO Sijia, LIU Jiaren. Effects of phytochemicals in cancer chemoprevention[J]. Journal of Practical Oncology, 2020, 34(5): 460-465.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.05.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2020/V34/I5/460

References

1 Chen W,Zheng R,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
2 Grosso G,Bella F,Godos J,et al.Possible role of diet in cancer:systematic review and multiple meta-analyses of dietary patterns,lifestyle factors,and cancer risk[J].Nutr Rev,2017,75(6):405-419.
3 Walczak K,Marciniak S,Rajtar G.Cancer chemoprevention-selected molecular mechanisms[J].Postepy Hig Med Dosw(Online),2017,71:149-161.
4 Liu Y,Liu M,Li B,et al.Fresh raspberry phytochemical extract inhibits hepatic lesion in a Wistar rat model[J].Nutr Metab(Lond),2010,7(1):84.
5 Liu JR,Sun XR,Dong HW,et al.Beta-ionone suppresses mammary carcinogenesis,proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat[J].Int J Cancer,2008,122(12):2689-2698.
6 Liu JR,Dong HW,Chen BQ,et al.Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat[J].J Agric Food Chem,2009,57(1):297-304.
7 Zhang JS,Zhang SJ,Li Q,et al.Tocotrienol-Rich Fraction(TRF)suppresses the growth of human colon cancer xenografts in Balb/C Nude mice by the Wnt pathway[J].PLoS One,2015,10(3):e0122175.
8 Sun W,Wang Q,Chen B,et al.Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling[J].Br J Nutr,2008,99(6):1247-1254.
9 Sun WG,Song RP,Wang Y,et al.Gamma-tocotrienol-inhibited cell proliferation of human gastric cancer by regulation of nuclear factor-kappaB activity[J].J Agric Food Chem,2019,67(1):441-451.
10 Milani A,Basirnejad M,Shahbazi S,et al.Carotenoids:biochemistry,pharmacology and treatment[J].Br J Pharmacol,2017,174(11):1290-1324.
11 Ribeiro D,Freitas M,Silva AMS,et al.Antioxidant and pro-oxidant activities of carotenoids and their oxidation products[J].Food Chem Toxicol,2018,120:681-699.
12 Qiao YQ,Jiang PF,Gao YZ.Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation[J].Arch Med Sci,2018,14(3):617-624.
13 Liu JR,Dong HW,Sun XR,et al.Effects of beta-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA[J].Nutr Cancer,2010,62(1):58-65.
14 Liu Q,Dong HW,Sun WG,et al.Apoptosis initiation of beta-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway[J].Arch Toxicol,2013,87(3):481-490.
15 Dong HW,Zhang S,Sun WG,et al.Beta-ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway[J].Arch Toxicol,2013,87(10):1797-1808.
16 Dong HW,Wang K,Chang XX,et al.Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity[J].Arch Toxicol,2019,93(10):2993-3003.
17 Anantharaju PG,Gowda PC,Vimalambike MG,et al.An overview on the role of dietary phenolics for the treatment of cancers[J].Nutr J,2016,15(1):99.
18 Wen L,Jiang Y,Yang J,et al.Structure,bioactivity,and synthesis of methylated flavonoids[J].Ann N Y Acad Sci,2017,1398(1):120-129.
19 Kawabata K,Mukai R,Ishisaka A.Quercetin and related polyphenols:new insights and implications for their bioactivity and bioavailability[J].Food Funct,2015,6(5):1399-1417.
20 Ben Yehuda Greenwald M,Frusic-Zlotkin M,Soroka Y,et al.Curcumin protects skin against UVB-induced cytotoxicity via the Keap1-Nrf2 pathway:the use of a microemulsion delivery system[J].Oxid Med Cell Longev,2017,2017:5205471.
21 Weng W,Goel A.Curcumin and colorectal cancer:an update and current perspective on this natural medicine[J].Semin Cancer Biol,2020[Epub ahead of print].
22 Galiniak S,Aebisher D,Bartusik-Aebisher D.Health benefits of resveratrol administration[J].Acta Biochim Pol,2019,66(1):13-21.
23 Shang A,Cao SY,Xu XY,et al.Bioactive compounds and biological functions of garlic(Allium sativum L)[J].Foods,2019,8(7):1-31.
24 Almatroodi SA,Alsahli MA,Almatroudi A,et al.Garlic and its active compounds:a potential candidate in the prevention of cancer by modulating various cell signalling pathways[J].Anticancer Agents Med Chem,2019,19(11):1314-1324.
25 Xiong T,Liu XW,Huang XL,et al.Tristetraprolin:a novel target of diallyl disulfide that inhibits the progression of breast cancer[J].Oncol Lett,2018,15(5):7817-7827.
26 Hashmi MA,Khan A,Farooq U,et al.Alkaloids as cyclooxygenase inhibitors in anticancer drug discovery[J].Curr Protein Pept Sci,2018,19(3):292-301.
27 Wu J,Wang L,Du X,et al.Alpha-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA138 expression[J].Oncol Rep,2018,39(3):1163-1172.
28 Shalom J,Cock IE.Terminalia ferdinandiana exell.fruit and leaf extracts inhibit proliferation and induce apoptosis in selected human cancer cell lines[J].Nutr Cancer,2018,70(4):579-593.
29 Sreelatha S,Dinesh E,Uma C.Antioxidant properties of Rajgira(Amaranthus paniculatus)leaves and potential synergy in chemoprevention[J].Asian Pac J Cancer Prev,2012,13(6):2775-2780.
30 Eberhardt MV,Lee CY,Liu RH.Antioxidant activity of fresh apples[J].Nature,2000,405(6789):903-904.
31 Su X,Wang Z,Liu J.In vitro and in vivo antioxidant activity of Pinus koraiensis seed extract containing phenolic compounds[J].Food Chem,2009,117(4):681-686.
32 Shin SS,Song JH,Hwang B,et al.HSPA6 augments garlic extract-induced inhibition of proliferation,migration,and invasion of bladder cancer EJ cells;Implication for cell cycle dysregulation,signaling pathway alteration,and transcription factor-associated MMP-9 regulation[J].PLoS One,2017,12(2):e0171860.
33 Khan F,Pandey P,Upadhyay TK,et al.Anti-cancerous effect of rutin against HPV-C33A cervical cancer cells via G0/G1 cell cycle arrest and apoptotic induction[J].Endocr Metab Immune Disord Drug Targets,2019,20(3):409.
34 Kwak AW,Choi JS,Liu K,et al.Licochalcone C induces cell cycle G1 arrest and apoptosis in human esophageal squamous carcinoma cells by activation of the ROS/MAPK signaling pathway[J].J Chemother,2020[Epub ahead of print].
35 张浩鹏,李国东,魏九峰,等.红树莓提取物抑制肝癌SMMC-7721细胞增殖的实验研究[J].中国肿瘤,2019,28(2):155-160.
36 Huang J,Yang B,Xiang T,et al.Diallyl disulfide inhibits growth and metastatic potential of human triple-negative breast cancer cells through inactivation of the beta-catenin signaling pathway[J].Mol Nutr Food Res,2015,59(6):1063-1075.
37 Kim SH,Yoo ES,Woo JS,et al.Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation[J].Eur J Pharmacol,2019,860:172568.
38 董宏伟,王琪,金德利,等.β-紫罗兰酮诱导人乳腺癌细胞(ER+)凋亡作用[J].中国公共卫生,2015,31(2):193-195.
39 Chen HS,Liu M,Shi LJ,et al.Effects of raspberry phytochemical extract on cell proliferation,apoptosis,and serum proteomics in a rat model[J].J Food Sci,2011,76(8):192-198.
40 Liu M,Lin LQ,Song BB,et al.Cranberry phytochemical extract inhibits SGC-7901 cell growth and human tumor xenografts in Balb/c nu/nu mice[J].J Agric Food Chem,2009,57(2):762-768.
41 Daghero H,Pagotto R,Vallespi MG,et al.Generation of stable reporter breast and lung cancer cell lines for NF-kappaB activation studies[J].J Biotechnol,2019,301(2019):79-87.
42 Coker-Gurkan A,Celik M,Ugur M,et al.Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-kappaB signaling and polyamine metabolism in breast cancer cells[J].Amino Acids,2018,50(8):1045-1069.
43 Schwertheim S,Wein F,Lennartz K,et al.Curcumin induces G2/M arrest,apoptosis,NF-kappaB inhibition,and expression of differentiation genes in thyroid carcinoma cells[J].J Cancer Res Clin Oncol,2017,143(7):1143-1154.
44 蒋参,熊慧生,巫桁锞,等.姜黄素对前列腺癌细胞生物学行为的抑制作用[J].解放军预防医学杂志,2018,1(36):80-83.
45 Tyagi AK,Prasad S,Majeed M,et al.Calebin A,a novel component of turmeric,suppresses NF-kappaB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization[J].Phytomedicine,2017,34(2017):171-181.
46 Wu TC,Chan ST,Chang CN,et al.Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-kappaB signaling in A549cells[J].Chem Biol Interact,2018,292(2018):101-109.
47 Buhrmann C,Yazdi M,Popper B,et al.Evidence that TNF-beta induces proliferation in colorectal cancer cells and resveratrol can down-modulate it[J].Exp Biol Med(Maywood),2019,244(1):1-12.
48 Song L,Guo Y,Xu B.Expressions of Ras homolog gene family,member A(RhoA)and Cyclooxygenase-2(COX-2)proteins in early gastric cancer and their role in the development of gastric cancer[J].Med Sci Monit,2017,23:2979-2984.
49 Kiraly AJ,Soliman E,Jenkins A,et al.Apigenin inhibits COX-2,PGE2,and EP1 and also initiates terminal differentiation in the epidermis of tumor bearing mice[J].Prostaglandins Leukot Essent Fatty Acids,2016,104(2016):44-53.
50 Dash R,Uddin MM,Hosen SM,et al.Molecular docking analysis of known flavonoids as duel COX-2 inhibitors in the context of cancer[J].Bioinformation,2015,11(12):543-549.
51 Owczarek K,Hrabec E,Fichna J,et al.Flavanols from Japanese quince(Chaenomeles japonica)fruit suppress expression of cyclooxygenase-2,metalloproteinase-9,and nuclear factor-kappaB in human colon cancer cells[J].Acta Biochim Pol,2017,64(3):567-576.
52 Han H,Lim JW,Kim H.Lycopene inhibits activation of epidermal growth factor receptor and expression of cyclooxygenase-2 in gastric cancer cells[J].Nutrients,2019,11(9):2113.
53 Zhang YH,Ma K,Liu JR,et al.Gamma-tocotrienol inhibits the invasion and migration of human gastric cancer cells through downregulation of cyclooxygenase-2 expression[J].Oncol Rep,2018,40(2):999-1007.
54 Zhang H,Liu J,Li G,et al.Fresh red raspberry phytochemicals suppress the growth of hepatocellular carcinoma cells by PTEN/AKT pathway[J].Int J Biochem Cell Biol,2018,104:55-65.
55 Avtanski DB,Nagalingam A,Kuppusamy P,et al.Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-beta-catenin signaling axis in a microRNA-34a dependent manner[J].Oncotarget,2015,6(18):16396-16410.
56 Su B,Su J,Zeng Y,et al.Diallyl disulfide suppresses epithelial-mesenchymal transition,invasion and proliferation by downregulation of LIMK1 in gastric cancer[J].Oncotarget,2016,7(9):10498-10512.
57 Zhao Z,Malhotra A,Seng WY.Curcumin modulates hepatocellular carcinoma by reducing UNC119 expression[J].J Environ Pathol Toxicol Oncol,2019,38(3):195-203.
58 Jin G,Yang Y,Liu K,et al.Combination curcumin and(-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway[J].Oncogenesis,2017,6(10):e384.
59 Liu YZ,Wu K,Huang J,et al.The PTEN/PI3K/Akt and Wnt/β-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation[J].Int J Oncol,2014,45(1):104-112.
60 Liu M,Liu RH,Song BB,et al.Antiangiogenetic effects of 4 varieties of grapes in vitro[J].J Food Sci,2010,75(6):99-104.
61 Festuccia C,Mancini A,Gravina GL,et al.Antitumor effects of saffron-derived carotenoids in prostate cancer cell models[J].Biomed Res Int,2014,2014:135048.
62 Sak K.Site-specific anticancer effects of dietary flavonoid quercetin[J].Nutr Cancer,2014,66(2):177-193.
63 常晓霞,宋冰冰,刘家仁.植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展[J].实用肿瘤学杂志,2019,33(1):67-71.

[1]	LI Ji, CHEN Yang, ZHANG Maorong, YANG Zhao, TANG Xian, WEN Hongmei. Analysis of proportion and trend prediction of disability-adjusted life years attributed to aging population in common digestive system malignant tumors in China [J]. Journal of Practical Oncology, 2025, 39(5): 372-380.
[2]	LIU Lu, ZHU Jiahe, WANG Jia, ZHANG Bolun, XING Dehao, DING Gaoheng, WEI Xingmin, LIU Yuqin. Prediction analysis of incidence trend and age-period-cohort model of esophageal cancer in cancer registration areas of Gansu Province from 2010 to 2021 [J]. Journal of Practical Oncology, 2025, 39(5): 393-399.
[3]	LI Yun, SHI Pinghui. Analysis of gastroscopic screening and follow-up results among high-risk populations for gastric cancer in Gejiu City,Yunnan Province [J]. Journal of Practical Oncology, 2025, 39(5): 405-411.
[4]	LI Yifan, QIN Chuanyu, ZENG Xi, LU Yajiao, LIAO Guangdong, KANG Leni, YANG Ying, ZHOU Min, XI Mingrong, YANG Chunxia, LI Jing. Analysis of the acceptance and influencing factors of self-collection urine HPV testing in cervical cancer screening [J]. Journal of Practical Oncology, 2025, 39(5): 412-417.
[5]	LI Xudong, LIU Tong. The single cell transcriptome sequencing reveals the role and prognostic value of PCLAF and ERO1A in the progression of breast cancer [J]. Journal of Practical Oncology, 2025, 39(5): 418-427.
[6]	ZHANG Xuan, LI Juan, FANG Chuanfeng, TIAN Hong, LIU Jiaren. Research progress of phytochemicals in tumor immunotherapy [J]. Journal of Practical Oncology, 2025, 39(5): 428-432.
[7]	XIN Xin, XIONG Wenjing, ZHANG Chunnuan, LI Xiaojing, GAO Xue, ZHANG Yue. Lactylation modification:an emerging target in cancer therapy [J]. Journal of Practical Oncology, 2025, 39(5): 433-436.
[8]	LUO Qiyuan, SHAO Hongchao, ZHOU Shaohua, YE Mushi. The current research status and prospect of the pathogenesis,influencing factors and surgical prevention and treatment strategies of inguinal hernia after prostate cancer surgery [J]. Journal of Practical Oncology, 2025, 39(5): 445-449.
[9]	MU Huijuan, LI Yanxia, MA Xiang, ZHU Tiancen, NA Jun, YAN Han, XING Liying. The 40-Year development history and prospects of cancer registration work in Liaoning Province [J]. Journal of Practical Oncology, 2025, 39(4): 267-271.
[10]	MA Dongqiong, YANG Cangjiang, ZHU Yunfang, WEN Hongmei, CAO Jidong, DAI Tangyan, LEI Guoyan, LI Dongke, SHI Qingping. Incidence and mortality of female breast cancer in cancer registration areas of Yunnan Province in 2020 and trend analysis from 2012 to 2020 [J]. Journal of Practical Oncology, 2025, 39(4): 272-277.
[11]	CHEN Lili, BAI Mingyu, ZHAO Bo, LI Yanxia, MA Xiang. Analysis of lung cancer death trend among urban residents in Yingkou City from 2013 to 2021 [J]. Journal of Practical Oncology, 2025, 39(4): 284-287.
[12]	FU Hongchen, CHENG Huirong, TANG Xian, WEN Hongmei, CHEN Yang, SHI Qingping, REN Siying, ZHU Yunfang, WU Fuxian. Analysis for the incidence and mortality of colorectal cancer in cancer registration areas of Yunnan Province in 2020,and the trend from 2012 to 2020 [J]. Journal of Practical Oncology, 2025, 39(4): 288-293.
[13]	ZHU Tiancen, LI Yanxia, REN Fanghan, DAI Xiaoze, LIU Yang, MU Huijuan. Analyses for the epidemic situation of malignant tumors in cancer registration areas of Liaoning Province in 2021 [J]. Journal of Practical Oncology, 2025, 39(4): 294-300.
[14]	GAO Yumeng, LI Kai, LIU Shanyi. Analysis of colorectal cancer screening results for urban residents in Ningbo City from 2019 to 2023 [J]. Journal of Practical Oncology, 2025, 39(4): 301-305.
[15]	ZHAO Jiangang, LIU Yifan, ZHAO Guangyuan, BAO Shuangzhen, LIU Fangzhen, YIN Changheng, LIU Hongbo. Impacts of LINC00511 on proliferation,apoptosis,and epithelial mesenchymal transition of colorectal cancer cells by regulating the miR-150-5p/PHF1 axis [J]. Journal of Practical Oncology, 2025, 39(4): 306-315.

Effects of phytochemicals in cancer chemoprevention

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments