肝癌共病抑郁分子机制的研究进展

doi:10.11904/j.issn.1002-3070.2022.03.008

Abstract

Abstract: The incidence of comorbid depression in patients with liver cancer is extremely high.The depression is an adverse factor affecting the prognosis of liver cancer patients.Understanding the molecular mechanism of liver cancer comorbid and depression is crucial for the diagnosis and treatment of the disease.Therefore,this paper reviews the pathogenesis involved in both as a starting point and combines the existing research results from autonomic dysfunction,hypothalamic-pituitary-adrenal(HPA)axis dysfunction,inflammatory cytokines imbalance,abnormal regulation of 5-hydroxytryptamine(5-HT)system,imbalance of intestinal flora,and oxidative stress are reviewed.

Key words: Liver cancer, Depression, Comorbidities, Molecular mechanism

CLC Number:

R735.7

TANG Rubing, WANG Qi, YOU Xuemei. Research progress in molecular mechanism of liver cancer comorbid and depression[J]. Journal of Practical Oncology, 2022, 36(3): 239-244.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2022.03.008

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2022/V36/I3/239

References

1 International Agency for Research on Cancer.The global cancer observatory.2020[EB/OL].[2020-07-01].https://gco.iarc.fr/today/data/factsheets/cancers/11-Liver-fact-sheet.pdf.
2 Malhi GS,Mann JJ.Depression[J].Lancet,2018,392(10161):2299-2312.
3 Jin SH,Tian J.Prevalence of anxiety and depression and their risk factors in Chinese cancer patients[J].Supportive Care Cancer,2013,22(2):453-459.
4 韦珏伶,向骁,赵凌云,等.HSP90AA1/HSPA8在合并抑郁情绪的肝癌患者中的表达及临床意义[J].中国肿瘤,2019,28(5):387-394.
5 赵凌云,韦珏伶,赵新华,等.巴塞罗那(BCLC)B/C期肝癌患者术前抑郁相关因素分析及对免疫功能的影响[J].现代肿瘤医学,2018,26(11):1727-1732.
6 贾勇.抑郁与肝癌发生、复发风险的相关性研究[D].长春:吉林大学,2019.
7 Dai S,Mo Y,Wang Y,et al.Chronic stress promotes cancer development[J].Front Oncol,2020,10:1492.
8 Lake CR,Pickar D,Ziegler MG,et al.High plasma norepinephrine levels in patients with major affective disorder[J].Am J Psychiatry,1982,139(10):1315-1318.
9 Mravec B,Horvathova L,Hunakova L.Neurobiology of cancer:the role of β-adrenergic receptor signaling in various tumor environments[J].Int J Mol Sci,2020,21(21):1-24.
10 Jiang W,Li Y,Li ZZ,et al.Chronic restraint stress promotes hepatocellular carcinoma growth by mobilizing splenic myeloid cells through activating β-adrenergic signaling[J].Brain,Behav Immu,2019,80:825-838.
11 Jiang W,Li Y,Wei W,et al.Spleen contributes to restraint stress induced hepatocellular carcinoma progression[J].Int Immunopharmacol,2020,83:106420.
12 Lin XH,Liu HH,Hsu SJ,et al.Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop[J].J Clin Cancer Res,2020,39(1):64-80.
13 沈锋,林间,王海波.肝细胞癌免疫微环境研究进展及未来方向[J].中国实用外科杂志,2021,41(1):42-47.
14 Reiche EM,Nunes SO,Morimoto HK.Stress,depression,the immune system,and cancer[J].Lancet Oncol,2004,5(10):617-625.
15 Zhao Y,Jia Y,Shi T,et al.Depression promotes hepatocellular carcinoma progression through a glucocorticoids mediated up-regulation of PD-1 expression in tumor infiltrating NK Cells[J].Carcinogenesis,2019,40(9):1132-1141.
16 Feng Z,Liu L,Zhang C,et al.Chronic restraint stress attenuates p53 function and promotes tumorigenesis[J].Proc Natl Acad Sci U S A,2012,109(18):7013-7018.
17 Marra F,Tacke F.Roles for chemokines in liver disease[J].Gastroenterology,2014,147(3):577-594.
18 Wohleb ES,Franklin T,Iwata M,et al.Integrating neuroimmune systems in the neurobiology of depression[J].Nat Rev Neurosci,2016,17(8):497-511.
19 Fan N,Luo Y,Ou Y,et al.Altered serum levels of TNF-α,IL-6,and IL-18 in depressive disorder patients[J].Hum Psychopharmacol,2017,32(4):1002.
20 Carboni L,McCarthy DJ,Delafont B,et al.Biomarkers for response in major depression:comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies[J].Transl Psychiatry,2019,9(1):182-193.
21 Jin K,Lu J,Yu Z,et al.Linking peripheral IL-6,IL-1β and hypocretin-1 with cognitive impairment from major depression[J].J Affect Disord,2020,277:204-211.
22 Tartour E,Pere H,Maillere B,et al.Angiogenesis and immunity:a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy[J].Cancer Metastasis Rev,2011,30(1):83-95.
23 Voronov E,Shouval D,Krelin Y,et al.IL-1 is required for tumor invasiveness and angiogenesis[J].Proc Natl Acad Sci U S A,2003,100(5):2645-2650.
24 Hammam O,Mahmoud O,Zahran M,et al.A possible role for TNF-α in coordinating inflammation and angiogenesis in chronic liver disease and hepatocellular carcinoma[J].Gastrointest Cancer Res,2013,6(4):107-114.
25 赵凤娟,王琪,赵新华,等.抑郁介导肿瘤免疫微环境诱导肝癌不良预后研究[J].中国肿瘤,2021,30(3):234-240.
26 Illman J,Corringham R,Robinson D,et al.Are inflammatory cytokines the common link between cancer-associated cachexia and depression[J].J Support Oncol,2005,3(1):37-50.
27 Adinolfi LE,Nevola R,Rinaldi L,et al.Chronic hepatitis C virus infection and depression[J].Clin Liver Dis,2017,21(3):517-534.
28 Lesurtel M,Graf R,Aleil B,et al.Platelet-derived serotonin mediates liver regeneration[J].Science,2006,312(5770):104-107.
29 Soll C,Jang JH,Riener M,et al.Serotonin promotes tumor growth in human hepatocellular cancer[J].Hepatology,2010,51(4):1244-1254.
30 马韵涵,潘宇飞,董立巍,等.5-羟色胺可促进肝细胞癌的发生与发展[J].肿瘤,2016,36(5):521-529.
31 Pyroja S,Joseph B,Paulose C.Increased 5-HT2C receptor binding in the brain stem and cerebral cortex during liver regeneration and hepatic neoplasia in rats[J].J Neurol Sci,2007,254(1/2):3-8.
32 Zhang H,Xu H,Tang Q,et al.The selective serotonin reuptake inhibitors enhance the cytotoxicity of sorafenib in hepatocellular carcinoma cells[J].Anticancer Drugs,2021,32(8):793-801.
33 Chen V,Lu M,Yang Y,et al.Antidepressant use and hepatocellular carcinoma in patients with hepatitis C who had received interferon therapy:a population-based cohort study[J].J Affect Disord,2019,253:147-153.
34 Li＇ skiewicz P,Kaczmarczyk M,Misiak B,et al.Analysis of gut microbiota and intestinal integrity markers of inpatients with major depressive disorder[J].Prog Neuropsychopharmacology Biol Psychiatry,2021,106:110076.
35 Pennisi E.Gut bacteria linked to mental well-being and depression[J].Science,2019,363(6427):569.
36 Butler M,Cryan J,Dinan T.Man and the microbiome:A new theory of everything[J].Annu Rev Clin Psychol,2019,15(1):371-398.
37 Schmidt C.Mental health:thinking from the gut[J].Nature,2015,518(7540):12-15.
38Golonka RM,Vijay-Kumar M.Atypical immunometabolism and metabolic reprogramming in liver cancer:Deciphering the role of gut microbiome[J].Adv Cancer Res,2021,149:171-255.
39 Stevens BR,Goel R,Seungbum K,et al.Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression[J].Gut,2018,67(8):1555-1557.
40 Tripathi A,Debelius J,Brenner DA,et al.The gut-liver axis and the intersection with the microbiome[J].Nat Rev Gastroenterol Hepatol,2018,15(7):397-411.
41 Dapito D,Mencin A,Gwak G,et al.Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4[J].Cancer Cell,2012,21(4):504-516.
42 Zhang HL,Yu LX,Yang W,et al.Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats[J].J Hepatol,2012,57(4):803-812.
43 Ferrere G,Wrzosek L,Cailleux F,et al.Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice[J].J Hepatol,2017,66(4):806-815.
44 Reiter A,Bengesser SA,Hauschild AC,et al.Interleukin-6 gene expression changes after a 4-week intake of a multispecies probiotic in major depressive disorder-preliminary results of the PROVIT study[J].Nutrients,2020,12(9):2575-2592.
45 Bhatt S,Nagappa AN,Patil CR.Role of oxidative stress in depression[J].Drug Discov Today,2020,25(7):1270-1276.
46 Leone V,Ali A,Weber A,et al.Liver inflammation and hepatobiliary cancers[J].Trends Cancer,2021,7(7):606-623.
47 Reuter S,Gupta SC,Chaturvedi MM,et al.Oxidative stress,inflammation,and cancer:how are they linked[J].Free Radic Biol Med,2010,49(11):1603-1616.

[1]	REN Fenghai, ZHU Kaibin, WANG Yanbo, ZHOU Fucheng, PANG Sainan, CHEN Lantao. Effects of NFATc1 on the proliferation,apoptosis and invasion of human lung adenocarcinoma cells [J]. Journal of Practical Oncology, 2021, 35(5): 402-407.
[2]	ZHU Yunfang, CHEN Yang, ZHU Linfang, SHI Qingping, CHENG Huirong, REN Siying, WEN Hongmei. The incidence and mortality of liver cancer in Yunnan cancer registration areas in 2016 and the change trend from 2011 to 2016 [J]. Journal of Practical Oncology, 2021, 35(2): 97-102.
[3]	HU Qihui, DU Yichao, HE Kai, FU Wenguang, XIA Xianming. The role of endoplasmic reticulum stress in liver cancer [J]. Journal of Practical Oncology, 2021, 35(2): 160-164.
[4]	BAI Mingyu, CHEN Lili. Analytic death causes of liver cancer among urban residents in Yingkou city from 2015 to 2019 [J]. Journal of Practical Oncology, 2020, 34(6): 500-503.
[5]	SHI Linna, SUI Hong. Progress and challenges of immune checkpoint inhibitor therapy for primary hepatocellular carcinoma [J]. Journal of Practical Oncology, 2020, 34(6): 560-564.
[6]	HAN Jing, PU Yan, LIU Huibin. Effects of SKA1 on cell proliferation and apoptosis of renal cell carcinoma and its molecular mechanism [J]. Journal of Practical Oncology, 2020, 34(5): 404-411.
[7]	ZHANG Mengzhe, KANG Xiangdong. Research progress on the relationship between Krüpple-like transcription factor 4 and the development of colorectal cancer [J]. Journal of Practical Oncology, 2020, 34(5): 456-459.
[8]	ZHAO Rencheng, LIN Zitang, YU Weijun, LEI Lin, LIU Zheng, XU Ying, GUO Yanfang, PENG Ji. Analysis of the prevalence of five cancer risks among permanent residents aged 40~74 years old in Baoan District,Shenzhen,2017—2019 [J]. Journal of Practical Oncology, 2020, 34(4): 315-320.
[9]	CHEN Lantao, YAN We, LIU Jinglei, YAO Lei. Effect of tetrandrine on lung cancer H1299 cells and A549 cells and its molecular mechanism [J]. Journal of Practical Oncology, 2020, 34(2): 126-132.
[10]	LIU Guangxia, ZHAO Lianchun, CHEN Fang, JIA Qian, GAO Wei, HOU Zhan, LU Yamin. Effect and mechanism of ZCCHC12 on malignant transformation of thyroid cells [J]. Journal of Practical Oncology, 2020, 34(2): 133-138.
[11]	LI Susu, ZHOU Chunxiang. Two-way regulation of NKT cells on immune response to liver cancer [J]. Journal of Practical Oncology, 2019, 33(6): 540-543.
[12]	LI Yafei, ZHANG Xiao, WANG Xuefei, WENG Mingjiao, WANG Tianzhen. Effect of RNA-binding protein Lin28 on the development of malignant tumors and its molecular mechanism [J]. Journal of Practical Oncology, 2019, 33(5): 456-460.
[13]	ZHAO Fengjuan, WANG Qi, REN Yunhong, WEI Jueling, LI Lequn, ZHAO Xinhua, TANG Juan, YOU Xuemei. Changes of serum CRP and hs-CRP levels in patients with liver cancer and depression and their influence on prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 27-33.
[14]	KAN Jun, ZHOU Daihan, ZHANG Enxin. Research progress in tumor with cardiovascular disease [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 558-561.
[15]	FAN Ningning, GENG Jingshu. The expression and role of LncRNA MEG3 in human glioma cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 219-223.

Research progress in molecular mechanism of liver cancer comorbid and depression

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments