Abstract: Although surgery,radiotherapy and chemotherapy have made great progress,pancreatic cancer is still the most fatal malignant tumor,with a 5-year overall survival rate of only about 4%.Many studies have demonstrated that the local recurrence of pancreatic cancer is an important cause of high mortality,and the failure rate after local excision is still as high as 50~80%.Therefore,how to improve the local control rate of pancreatic cancer has been a hot spot of concern.Due to the adjacent organs and tissues(such as bone marrow,spinal cord,kidney,liver,intestine,etc.),the dose of external irradiation(EBRT)is limited.Increasing local control rates and reducing treatment side effects are trends in future treatments.Intraoperative radiotherapy has the advantages of dosimetry and direct vision treatment to be increasingly used in the treatment of pancreatic cancer,becoming an important part of comprehensive treatment.This article summarizes the clinical research results of intraoperative radiotherapy for pancreatic cancer in recent years,in order to provide the reference for clinicians.

Key words: Pancreatic cancer, Intraoperative radiotherapy(IORT), Radiation therapy, Progression