单细胞测序技术在头颈部恶性肿瘤中的研究与发展

doi:10.11904/j.issn.1002-3070.2021.05.016

Abstract

Abstract: Single cell sequencing is to sequence the genetic information of a single cell,which can better understand the differences amongst cells and solve the heterogeneity problem caused by ordinary sequencing.Head and neck malignant tumors have become the sixth leading cause of death from cancer-related diseases.Single-cell sequencing technology is used to reveal the heterogeneity of head and neck malignant tumors,describe the microenvironment of head and neck malignant tumors,and evaluate the invasion and metastasis of head and neck malignant tumors.The evaluation of therapeutic effects and treatment resistance and exploration of the role of circulating tumor cells have greatly promoted the research on the occurrence and development of head and neck malignant tumors and the exploration of individualized treatment options.This review aims to outline the mechanism and significance of single-cell sequencing,and summarize its research progress in malignant tumors of head and neck.

Key words: Single cell sequencing, Malignant tumors of head and neck, Heterogeneity

CLC Number:

R739.6

FAN Lin, TIAN Linli, LIU Ming. Research and development of single-cell sequencing technology in head and neck malignant tumors[J]. Journal of Practical Oncology, 2021, 35(5): 472-475.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.05.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I5/472

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Research and development of single-cell sequencing technology in head and neck malignant tumors

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