MCM蛋白在消化系统肿瘤的研究进展

doi:10.11904/j.issn.1002-3070.2021.05.008

Abstract

Abstract: Minichromosome maintenance(MCM)proteins are important substances in the DNA replication process of eukaryotic cells,and are involved in the initiation and elongation of DNA replication.When certain factors cause the abnormal expression of MCM protein,cells in the quiescent phase start a new cell cycle,abnormal DNA replication occurs,and cells begin to proliferate indefinitely,resulting in tumorigenesis.Therefore,MCM protein is considered as a new tumor marker.Digestive system tumors are closely related to MCM protein.Exploring the MCM protein can bring new methods for the diagnosis and treatment of digestive system tumors.

Key words: Minichromosome maintenance protein, Digestive system tumor, Tumor marker

CLC Number:

R735

SHANG Changquan¹, LI Guodong¹, WEI Jiufeng¹, LIU Ming². Research progress of MCM protein in digestive system tumors[J]. Journal of Practical Oncology, 2021, 35(5): 431-435.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.05.008

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I5/431

References

1 Kelly TJ,Brown GW.Regulation of chromosome replication[J].Annu Rev Biochem,2000,69:829-880.
2 Yu S,Wang G,Shi Y,et al.MCMs in cancer:prognostic potential and mechanisms[J].Anal Cell Pathol,2020,2020:3750294.
3 Wang Y,Chen H,Zhang J,et al.MCM family in gastrointestinal cancer and other malignancies:From functional characterization to clinical implication[J].Biochim Bio Phys Acta Rev Cancer,2020,1874(2):188415.
4 Bochman ML,Schwacha A.The Mcm2-7 complex has in vitro helicase activity[J].Molecular Cell,2008,31(2):287-293.
5 Nowińska K,Dzigiel P.The role of MCM proteins in cell proliferation and tumorigenesis[J].Postepy Hig Med Dosw(Online),2010,64:627-635.
6 You Z,Ishimi Y,Masai H,et al.Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex[J].J Biol Chem,2002,277(45):42471-42479.
7 Cannone G,Visentin S,Palud A,et al.Structure of an octameric form of the minichromosome maintenance protein from the archaeon pyrococcus abyssi[J].Sci Rep,2017,8(7):42019.
8 Masai H,Matsumoto S,You ZY,et al.Eukaryotic chromosome DNA replication:where,when,and how?[J].Annu Rev Biochem,2010,79:89-130.
9 Truong LN,Wu XH.Prevention of DNA re-replication in eukaryotic cells[J].J Mol Cell Biol,2011,3(1):13-22.
10 Kanemaki MT.The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage[J].Cell Cycle,2013,12(9):1338-1339.
11 Bastajian N,Friesen H,Andrews BJ.Bck2 acts through the MADS box protein Mcm1 to activate cell-cycle-regulated genes in budding yeast[J].PLoS Genet,2013,9(5):e1003507.
12 Thu YM,Bielinsky AK.MCM10:one tool for all-Integrity,maintenance and damage control[J].Semin Cell Dev Biol,2014,6(30):121-30.
13 黄晓平,张旭,苏晓东,等.MCM4在食管癌组织中的表达与临床病理的关系[J].癌症,2007,23:(1):96-99.
14 Choy B,LaLonde A,Que J,et al.MCM4 and MCM7,potential novel proliferation markers,significantly correlated with Ki-67,Bmi1,and cyclin E expression in esophageal adenocarcinoma,squamous cell carcinoma,and precancerous lesions[J].Hum Pathol,2016,57:126-135.
15 Sirieix PS,O'Donovan M,Brown J,et al.Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus[J].Clin Cancer Res,2003,9(7):2560-2566.
16 Huang B,Hu B,Su M,et al.Potential role of minichromosome maintenance protein 2 as a screening biomarker in esophageal cancer high-risk population in China[J].Hum Pathol,2011,42(6):808-816.
17 Liu M,Li JS,Tian DP,et al.MCM2 expression levels predict diagnosis and prognosis in gastric cardiac cancer[J].Histol Histopathol,2013,28(4):81-92.
18 荣芳,王勇,王满贵,等.微小染色体维持蛋白4在胃癌中的表达及与幽门螺杆菌感染的关系[J].癌变·畸变·突变,2010,22(4):279-282.
19 Giaginis C,Giagini A,Tsourouflis G,et al.MCM-2 and MCM-5 expression in gastric adenocarcinoma:clinical significance and comparison with Ki-67 proliferative marker[J].Dig Dis Sci,2011,56(3):777-785.
20 谭宁平,李莉,张文静,等.MCM8在胃癌中的表达及其与临床病理特征及预后的相关性分析[J].胃肠病学和肝病学杂志,2020,29(10):1109-1113.
21 Guo F,Kong WN,Feng YC,et al.Comprehensive analysis of the expression and prognosis for MCMs in human gastric cancer[J].Technol Cancer Res Treat,2020,10(19):1-13.
22 Wei K,Joanna T,Anthony C,et al.MCM7 serves as a prognostic marker in diffuse-type gastric adenocarcino mand siRNA-mediated knockdown suppresses its oncogenic function[J].Oncol Rep,2014,31(5):2071-2078.
23 Liu Z,Li J,Chen J,et al.MCM family in HCC:MCM6 indicates adverse tumor features and poor outcomes and promotes S/G2 cell cycle progression[J].Bio Med Central,2018,18(1):200.
24 Yan L,Liang X,Huang H,et al.Adenosylmethionine affects cell cycle pathways and suppresses proliferation in liver cells[J].J Cancer,2019,10(18):4368-4379.
25 Nan YL,Hu YL,Liu ZK,et al.Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma[J].World J Gastroenterol,2016,22(24):5558-5567.
26 Liao X,Liu X,Yang C,et al.Distinct diagnostic and prognostic values of minichromosome maintenance gene expression in patients with hepatocellular carcinoma[J].J Cancer,2018,9(13):2357-2373.
27 Ishibashi Y,Kinugasa T,Akagi Y,et al.Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer[J].Anticancer Res,2014,34(8):4569-4575.
28 Nishihara K,Shomori K,Fujioka S,et al.Minichromosome maintenance protein 7 in colorectal cancer:implication of prognostic significance[J].Int J Oncol,2008,33(2):245-251.
29 Giaginis C,Georgiadou M,Dimakopoulou K,et al.Clinical significance of MCM-2 and MCM-5 expression in colon cancer:association with clinicopathological parameters and tumor proliferative capacity[J].Dig Dis Sci,2009,54(2):282-291.
30 Scarpini C,White V,Muralidhar B,et al.Improved screening for anal neoplasia by immunocytochemical detection of minichromosome maintenance proteins[J].Cancer Epidemiol Biomarkers Prev,2008,17(10):2855-2864.
31 Abe N,Matsuo K,Kumasaka T,et al.Systematic cytological evaluation and immunocytochemistry of minichromosome maintenance protein 2 and p53 significantly improve cytological diagnosis of pancreaticobiliary adenocarcinoma[J].J Med Dent Sci,2016,63(1):19-27.
32 Keane MG,Huggett MT,Chapman MH,et al.Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology[J].Br J Cancer,2017,116(3):349-355.
33 Liao X,Han C,Wang X,et al.Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy[J].Cancer Manag Res,2018,10:3255-3271.
34 Peng YP,Zhu Y,Yin LD,et al.The expression and prognostic roles of MCMs in pancreatic cancer[J].PLoS One,2016,11(10):e0164150.
35 Lei M.The MCM complex:its role in DNA replication and implications for cancer therapy[J].Curr Cancer Drug Targets,2005,5(5):365-380.
36 王蕾,余波光,吴文言.MBP-hmcm6融合蛋白的构建与表达[J].实用肿瘤学杂志,2005,19(5):321-324.

[1]	MA Mingrui, LIAN Jie, LIU Chao, LOU Changjie, ZHANG Yanqiao. Exploration of “immunotherapy moving forward” for digestive system tumors [J]. Journal of Practical Oncology, 2021, 35(3): 258-262.
[2]	HAN Bangling, WANG Yimin, XUE Yingwei. Research progress of vitamin D in tumors of digestive system [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 471-475.
[3]	WAN Jingxuan, LI Honghong, ZHOU Xiangxiang, Ma Lin. Analysis for risk factors of pulmonary thromboembolism in the stage Ⅳ of lung cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 214-244.
[4]	ZHU Tong,TAO Xuanchen,SUN Shibo. Research progress of MUC1 and MUC16 in gallblader carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 568-571.
[5]	TANG Zhijian,CUI Heng. The progress of human epididymis protein 4 in diagnosis and prognosis of ovarian cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2013, 27(3): 193-197.
[6]	QIAN Liuqi,LIU Qian,LIU Yi,ZHANG Shaohua,WANG Tao,WU Shikai,SONG Santai,LIU Bing,JIANG Zefei. Expression of circulating tumor cells in metastatic breast cancer patients and its relationship with multiple serum tumor markers [J]. PRACTICAL ONCOLOGY JOURNAL, 2012, 26(3): 220-224.
[7]	ZHANG Pengyu, LI Yuanyuan, LI Mingqi, SHI Xuekui, TAO Ji, XIAO Lin, WANG Yaxian. The expression of serous angiopoietin and its affeoh in hepatocellular carcinoma [J]. PRACTICAL ONCOLOGY JOURNAL, 2010, 24(6): 512-514.

Research progress of MCM protein in digestive system tumors

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments