骨髓微环境在白血病发病机制中的研究进展

doi:10.11904/j.issn.1002-3070.2023.06.012

Abstract

Abstract: The bone marrow microenvironment is a complex network structure composed of non-hematopoietic cells,hematopoietic stem cells,extracellular matrix,and various cytokines,which is beneficial to maintain normal hematopoietic function in the body.Once bone marrow microenvironment changes,the types and functions of cells in the bone marrow will change, thereby causing the occurrence of leukemia.Leukemia is a malignant clonal disease that is not only related to abnormal proliferation and differentiation of tumor cells,but also closely related to immune dysfunction.Exosomes,immune cells,mesenchymal cells and bone marrow stromal cells(BMSCs)in the bone marrow microenvironment all have immunoregulation effects and can participate in the formation of immune suppression in leukemia,leading to disease progression.Therefore,this article aims to review the mechanism and effects of bone marrow microenvironment on the pathogenesis of leukemia so as to provide new ideas for leukemia treatment.

Key words: Bone marrow microenvironment, Exosome, Immune cell, Mesenchymal cell, Leukaemia

CLC Number:

R733.7

WANG Li, WANG Kejin. Research progress on the bone marrow microenvironment in the pathogenesis of leukemia[J]. Journal of Practical Oncology, 2023, 37(6): 524-528.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2023.06.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2023/V37/I6/524

References

1 Wang Y,Lin Y.Hsa-mir-127 impairs survival of patients with glioma and promotes proliferation,migration and invasion of cancerous cells by modulating replication initiator 1[J].Neuroreport,2018,29(14):1166-1173.
2 Gagez AL,Duroux-Richard I,Leprêtre S,et al.Mir-125b and mir-532-3p predict the efficiency of rituximab-mediated lymphodepletion in chronic lymphocytic leukemia patients.A French Innovative Leukemia Organization study[J].Haematologica,2017,102(4):746-754.
3 Tao Y,Zhang J,Chen L,et al.Lncrna CD27-AS1 promotes acute myeloid leukemia progression through the mir-224-5p/PBX3 signaling circuit[J].Cell Death Dis,2021,12(6):510.
4 Hohtari H,Brück O,Blom S,et al.Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL[J].Leukemia,2019,33(7):1570-1582.
5 Abdul-Aziz AM,Sun Y,Hellmich C,et al.Acute myeloid leukemia induces protumoral p16INK4A-driven senescence in the bone marrow microenvironment[J].Blood,2019,133(5):446-456.
6 Xiao P,Sandhow L,Heshmati Y,et al.Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice[J].Blood Adv,2018,2(12):1480-1494.
7 Kitagawa M,Kurata M,Onishi I,et al.Bone marrow niches in myeloid neoplasms[J].Pathol Int,2020,70(2):63-71.
8 曹志杰,李怡爽,王慧君,等.成骨细胞龛通过上调白血病细胞IL-1的表达促进白血病干细胞增殖的研究[J].中国实验血液学杂志,2022,30(5):1348-1353.
9 Mahmoudvand S,Shokri S,Nakhaie M,et al.Small extracellular vesicles as key players in cancer development caused by human oncogenic viruses[J].Infect Agent Cancer,2022,17(1):58.
10 Zhao C,Du F,Zhao Y,et al.Acute myeloid leukemia cells secrete microRNA-4532-containing exosomes to mediate normal hematopoiesis in hematopoietic stem cells by activating the LDOC1-dependent STAT3 signaling pathway[J].Stem Cell Res Ther,2019,10(1):384.
11 Prieto D,Sotelo N,Seija N,et al.S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression[J].Blood,2017,130(6):777-788.
12 张红霞,王奎,吴广胜.miR-381-3p在急性髓系白血病中的表达及对白血病细胞增殖和凋亡的影响[J].安徽医科大学学报,2023,58(7):1164-1170.
13 温超,谢元康,陈懿建.miR-34a靶向调控HDAC1基因对急性髓系白血病细胞凋亡的影响[J].中国实验血液学杂志,2019,27(3):790-795.
14 Chen X,Yang S,Zeng J,et al.Mir-1271-5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2[J].Mol Med Rep,2019,19(1):508-514.
15 Wu WC,Shiu C,Tong TK,et al.Suppression of nk cell activation by jak3 inhibition:implication in the treatment of autoimmune diseases[J].J Immunol Res,2023,2023:8924603.
16 Paczulla AM,Rothfelder K,Raffel S,et al.Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion[J].Nature,2019,572(7768):254-259.
17 Li C,Long X,Liang P,et al.Analysis of microrna expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis[J].PeerJ,2022,10:e13498.
18 Fang Y,Garnier D,Lee TH,et al.PML-RARa modulates the vascular signature of extracellular vesicles released by acute promyelocytic leukemia cells[J].Angiogenesis,2016,19(1):25-38.
19 Xu ZJ,Gu Y,Wang CZ,et al.The M2 macrophage marker CD206:a novel prognostic indicator for acute myeloid leukemia[J].Oncoimmunology,2019,9(1):1683347.
20 宋建新,欧阳红梅,闻艳,等.急性白血病相关巨噬细胞的性质及rhIFN-γ 对其影响的研究[J].重庆医学,2019,48(19):3292-3296.
21 张晓冬,林晓媛.急性髓系白血病患者外周血调节性T细胞、辅助性T细胞17及其相关细胞因子的表达及意义[J].新乡医学院学报,2023,40(4):339-342.
22 Dong Q,Li G,Fozza C,et al.Levels and clinical significance of regulatory B cells and T cells in acute myeloid leukemia[J].Biomed Res Int,2020,2020:7023168.
23 刘俊闪,王国锋,郭明发.调节性T细胞、自然杀伤细胞、T淋巴细胞亚群在白血病患儿中表达及意义[J].医学理论与实践,2020,33(22):3824-3826.
24 Krętowska-Grunwald A,Sawicka-·Zukowska M,Kowalska M,et al.Significance of TH17 and Treg in treatment efficacy and outcome in pediatric acute lymphoblastic leukemia[J].Int J Mol Sci,2023,24(15):12323.
25 Yang ZG,Wen RT,Qi K,et al.The neuropilin-1 ligand,sema3a,acts as a tumor suppressor in the pathogenesis of acute leukemia[J].Anat Rec(Hoboken),2019,302(7):1127-1135.
26 Han Y,Dong Y,Yang Q,et al.Acute myeloid leukemia cells express icos ligand to promote the expansion of regulatory T cells[J].Front Immunol,2018,9(1):2227.
27 Cai J,Wang D,Zhang G,et al.The role of PD-1/PD-L1 axis in treg development and function:implications for cancer immunotherapy[J].Onco Targets Ther,2019,12(1):8437-8445.
28 Arandi N,Ramzi M,Safaei F,et al.Overexpression of indoleamine 2,3-dioxygenase correlates with regulatory T cell phenotype in acute myeloid leukemia patients with normal karyotype[J].Blood Res,2018,53(4):294-298.
29 Pan C,Fang Q,Liu P,et al.Mesenchymal stem cells with cancer-associated fibroblast-like phenotype stimulate SDF-1/CXCR4 axis to enhance the growth and invasion of B-cell acute lymphoblastic leukemia cells through cell-to-cell communication[J].Front Cell Dev Biol,2021,9:708513.
30 吴金娴,刘晓燕,黎鑫琦,等.急性髓系白血病来源骨髓间充质干细胞的基因表达谱和细胞因子表达[J].临床内科杂志,2022,39(8):531-534.
31 宁红梅,王军,苏永锋,等.初诊急性髓系白血病患者来源的骨髓间充质干细胞调节HL-60细胞的增殖、细胞周期和免疫表型[J].中国实验血液学杂志,2019,27(4):1259-1264.
32 Fathi E,Valipour B,Sanaat Z,et al.Interleukin-6,-8,and TGF-β secreted from mesenchymal stem cells show functional role in reduction of telomerase activity of leukemia cell via wnt5a/β-catenin and p53 pathways[J].Adv Pharm Bull,2020,10(2):307-314.
33 Nikkhah H,Safarzadeh E,Shamsasenjan K,et al.The effect of bone marrow mesenchymal stem cells on the granulocytic differentiation of HL-60 cells[J].Turk J Haematol,2018,35(1):42-48.
34 Li Q,Pang Y,Liu T,et al.Effects of human umbilical cord-derived mesenchymal stem cells on hematologic malignancies[J].Oncol Lett,2018,15(5):6982-6990.
35 陈文婷,黄莹,潘艳萍,等.TGFβ1在急性髓系白血病中的异常表达及其对白血病细胞的调控[J].海南医学院学报,2022,28(24):1889-1895.
36 陈雅琳,白天鸽,李瑶瑶,等.骨髓基质细胞HS-5分泌物白细胞介素-6对人急性髓细胞性白血病细胞系HL-60抗凋亡的作用[J].解剖学报,2020,51(1):32-39.

[1]	ZHOU Xingan, SU Nite, WU Xu, DA Lintai, DELEHEI Bateer. Research progress of exosomal lncRNA in squamous cell carcinoma [J]. Journal of Practical Oncology, 2023, 37(2): 160-163.
[2]	YU Yinping, LIN Jianan, WANG Lizhong, JIANG Weihua. Effects of cancer-derived exosomes on the biological beharior of breast cancer MCF-7 cells [J]. Journal of Practical Oncology, 2023, 37(1): 26-31.
[3]	LI Hao, TENG Lichen. Research status of exosomal circular RNA in prostate cancer [J]. Journal of Practical Oncology, 2023, 37(1): 92-96.
[4]	YUE Jie, YANG Qilin, SUN Xiangyu, SUN Yuming, MA Xiang, CHEN Dong, JING Guangping. Effects of exosomes derived from dental pulp stem cells on the proliferation and migration of oral squamous cell carcinoma CAL-27 and its mechanism [J]. Journal of Practical Oncology, 2022, 36(5): 398-403.
[5]	CHEN Han, LUO Xiaoyong, LI Chaoping, GUO Cairu, JU Wencui, ZHAI Yangyang, SHI Xinpeng. The effect of lncRNA CASC2 on the function and angiogenesis of colorectal cancer cells [J]. Journal of Practical Oncology, 2022, 36(2): 111-118.
[6]	SHI Jingtong, CHEN Minjie, SUN Yihua. Research progress in the role of malignant tumor-derived exosomes in the M2 polarization of macrophages [J]. Journal of Practical Oncology, 2022, 36(1): 59-63.
[7]	LONG Yuanhui, CHEN Xuesong. Research progress on the effect of psychological stress on immune cells in tumor microenvironment [J]. Journal of Practical Oncology, 2021, 35(5): 436-440.
[8]	SONG Jiayu, FENG Yue, WANG Zhao, ZHANG Yunyan. The latest research progress of the correlation between exosomes and gynecological malignant tumor [J]. Journal of Practical Oncology, 2020, 34(6): 571-575.
[9]	CHEN Du, QIAN Cheng. Research progress of mesenchymal cell-mediated chemotherapy resistance in tumor microenvironment of breast cancer [J]. Journal of Practical Oncology, 2020, 34(4): 382-386.
[10]	CAO Ning,XIA Bairong,LOU Ge. Research progress of HPV proteins,miRNAs and exosomes in the inflammation of cervical cancer [J]. Journal of Practical Oncology, 2020, 34(3): 282-285.
[11]	CUI Xueyang,XING Chengzhong. The research and application of liquid biopsy in the field of colorectal cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(4): 367-370.
[12]	SHEN Meiying, PANG Da. Regulation of long non-coding RNAs in the tumor microenvironment [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(1): 73-76.

Research progress on the bone marrow microenvironment in the pathogenesis of leukemia

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 12

Recommended Articles

Metrics

Comments