HPV蛋白、miRNAs和外泌体在宫颈癌炎症作用中的研究进展

doi:10.11904/j.issn.1002-3070.2020.03.018

Abstract

Abstract: Human papilloma virus(HPV)infection is the most important risk factor for cervical cancer.At present,many studies have shown that HPV protein is directly or indirectly involved in the occurrence of chronic inflammation,thereby promoting tumor development.Non-coding RNA(microRNA;miRNAs)is a regulator of gene expression and a key player in the inflammatory pathway.The abnormal expression of miRNAs may be related to the inflammatory response of cervical cancer.Exosomes are vesicles secreted by cells from the outside of cells,and these vesicles can act as a carrier to bind to the receptor.Recent studies have found that exosomes are involved in the inflammatory process and affect the immune response.In this review,we discuss the research progress of HPV proteins,miRNAs and exosomes in the inflammatory effects of cervical cancer.

Key words: Cervical cancer, Inflammatory Factors, HPV, microRNAs, Exosomes

CLC Number:

R737.33

CAO Ning,XIA Bairong,LOU Ge. Research progress of HPV proteins,miRNAs and exosomes in the inflammation of cervical cancer[J]. Journal of Practical Oncology, 2020, 34(3): 282-285.

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Research progress of HPV proteins,miRNAs and exosomes in the inflammation of cervical cancer

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