Abstract: Objective The aim of this study was to establish a practical and feasible prevention,and a treatment scheme of cardiovascular toxicity(CVT)induced by chemotherapy in cervical cancer based on known effective measures and to provide scientific guidance and basis for clinical treatment. Methods The risk of pre-chemotherapy CVT and post-chemotherapy CVT were evaluated in 164 subjects from November 2016 to January 2018.The Interrupted time series(ITS)model of CVT incidence before and after intervention was established.The CVT biomarkers and results of clinical examination before and after chemotherapy were compared in selected patieds.The effects of measures were evaluated. Results There was no difference in the ITS model of CVT incidence before and after intervention(P＞0.05).Among echocardiography examination results,the E peak velocity of mitral valve and E/A ratio increased,and the difference was statistically significant(P＜0.05),LVEF、FS、SV and A peak velocity of mitral valve had no differences(P＞0.05).There were no differences in ECG and double lower extremities arteriovenous ultrasonography results(P＞0.05).The level of sICAM-1,sTM,vWF and h-FABP decreased(P＜0.05),the levels of NO and eNOS increased(P＜0.05);there was no significant difference in the levels of hs-CRP and E-selectin(P＞0.05). Conclusion The comprehensive prevention and treatment program established in this study can improve the cervical cancer chemotherapy CVT microscopically,and further research should be carried out by expanding the sample size.

Key words: Interrupted time series trial, Cervical cancer, Cardiovascular toxicity, Chemotherapy, Translation