Abstract: Objective To study the expression of Pokemon、Ki-67 and its clinical significance in gastric cancer and normal gastric mucosa.Methods The Pokemon and Ki-67 in gastric cancer(n=125),normal gastric mucosa(n=25)was detected by RT-PCR.Results Pokemon protein expression was high in gastric cancer group,which was significantly different from the expression in normal gastric mucosa.It was highly expressed in gastric cancer and was related with stage of TNM and lymph node metastasis,but were not related with the age,sex and the size of tumor.Conclusion Pokemon and Ki-67 protein expression may be correlate with the carcinogenesis and genesis,development and metastasis of gastric cancer.Pokemon may be an effective target gene for therapy of gastric cancer,accordingly,which may develop a new way of gene therapy for gastric cancer.