PRACTICAL ONCOLOGY JOURNAL ›› 2012, Vol. 26 ›› Issue (5): 452-457.doi: 10.3969/j.issn.1002-3070.2012.05.015

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Features of PELP1/MNAR expression in tumor from north of China resident Han ethnic female primary breast cancer patients and its correlation with Ki-67

WANG Peng1,5,ZHANG Yanzhi2,SHI Mumu2,LI Shuzhi3,LI Yurong4,ZHU Hui5   

  1. 1.Department of Physiology,The Daqing Campus of Harbin Medical University,Daqing 163319,China;
    2.Department of Pathology,The Daqing Campus of Harbin Medical University,Daqing 163319;
    3.Medical Functional Experimental Center,The Daqing Campus of Harbin Medical University,Daqing 163319;
    4.Medical Functional Experimental Center,Harbin Medical University,Harbin 150081;
    5.Department of Physiology,Harbin Medical University,Harbin 150081
  • Received:2011-11-16 Online:2012-05-25 Published:2012-10-29

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Abstract: Objective To investigate the correlation of expression of proline-,glutamic acid-,leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor(PELP1/MNAR)with clinical index and Ki67 label index(Ki-67 LI)in tumor from North of China resident Han ethnic female breast cancer patients.Methods 98 cases of primary breast cancer and 22 cases of benign breast fibroadenoma tissues from North of China resident Han ethnic patients were collected.Expression levels of PELP1/MNAR both in breast cancer and fibroadenoma specimens as well as Ki-67 only in breast cancer specimens were detected by immunohistochemistry(IHC).Correlation analysis was performed to examine association between PELP1/MNAR expression and other clinical parameters as well as Ki-67 in breast cancer.Results The positive ratio of PELP1/MNAR in breast cancer was significantly higher than that in fibroadenoma(100% vs 72.7%,P＜0.001).The expression of PELP1/MNAR in breast cancer did not show significant correlation with age or pathological types,but appeared significantly positive correlation with clinical stage and lymph node metastatic state.A significant positive correlation between expression of PELP1/MNAR and Ki-67 LI in breast cancer was also found(r=0.247,P=0.014).Conclusion Higher expression of PELP1/MNAR in tumor is a character of North of China resident Han ethnic female primary breast cancer patients.PELP1/MNAR status may be served as a valuable pathological index in evaluating prognosis of primary breast cancer.

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