PRACTICAL ONCOLOGY JOURNAL ›› 2011, Vol. 25 ›› Issue (1): 49-52.doi: 10.3969/j.issn.1002-3070.2011.01.014

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The expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after transcatheter arterial chemoembolization

WANG Huiwen,LIU Ruibao,LIU Yan,SHEN Haiyang   

  1. Department of Intervention,the Affiliated Tumor Hospital of Harbin Medical University,Harbin 150081
  • Received:2010-11-02 Online:2011-01-25 Published:2012-02-21

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Abstract:

Objective To investigate the expression and significance of Caspase-3 and FAK in hepatocarcinoma infected with Hepatitis B Virus after TACE.Methods To collect thirty-eight surgical specimens of hepatocarcinoma after TACE,including twenty-seven cases infected with HBV and eleven cases with no HBV.The Caspase-3 and FAK in residual tissues of hepatocarcinoma were detected by using immunohistochemical SP method.Results The positive rate of Caspase-3 and FAK in HBV group were respectively 22.2% and 81.5%,and that of no HBV group were 63.6% and 36.4% respectively.The difference between the two groups was statistically significant(P=0.024;P=0.017).The expression of Caspase-3 and FAK in HBV group was negatively correlated(r=-0.433,P=0.020).Conclusion HBV could suppress the expression of Caspase-3 and up-regulate the expression of FAK.HBV effect the therapeutic effect of TACE.

Key words: HBV, Hepatocarcinoma, Caspase-3, FAK

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