Abstract: Objective The aim of this study was to explore the related factors affecting the efficacy of neoadjuvant chemotherapy in patients with Luminal A type breast cancer,so as to provide screening indicators for patients with Luminal A type breast cancer and ultimately provide reference for improving the efficacy of neoadjuvant chemotherapy. Methods The clinical data of patients with Luminal A type breast cancer who received preoperative neoadjuvant chemotherapy and surgical treatment in our hospital from August 23,2013 to November 1,2019 were retrospectively analyzed.A total of 191 patients with type A breast cancer met the inclusion criteria.RECIST1.1 score was used to evaluate the efficacy.According to the clinical efficacy,these patients were divided into the Cr+PR group and non Cr+PR group.The relationship between clinicopathological features,efficacy and the related factors affecting efficacy were analyzed. Results Amongst 191 cases of Luminal A type breast cancer,147 cases were clinically effective(147 in the CR+PR group 44 cases were not clinically effective(44 cases in the non-CR+PR group),and the clinical effective rate of 77.0%.The degradation rate of axillary lymph nodes was 26.8%(45/168).Age ≤50 years old,premenopausal state,estrogen receptor(ER)＜ 70%,progesterone receptor(PR)＜50% and tumor located in the lateral quadrant were associated with the clinical effective rate(P＜0.05).Logistic regression analysis showed that tumor location and clinical stage were independent factors affecting the clinical efficacy of neoadjuvant chemotherapy in patients with Luminal A type breast cancer(P＜0.05). Conclusion Patients with Luminal A type breast cancer distributed in the lateral quadrant and clinical stage Ⅲ are more likely to be clinically effective,and patients with Luminal A type breast cancer can be evaluated and screened before neoadjuvant chemotherapy,so as to improve the curative effect.

Key words: Luminal A type breast cancer;Neoadjuvant chemotherapy;Estrogen receptor;Pathological remission