PRACTICAL ONCOLOGY JOURNAL ›› 2011, Vol. 25 ›› Issue (1): 33-35.doi: 10.3969/j.issn.1002-3070.2011.01.010

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Clinical efficacy of ginsenoside Rg3 combined with chemotherapy treatment on non-small-cell lung cancer

WANG Yan1,LIU Jinglei1,ZHAO Hongli1,YANG Maopeng1,LI Xin1,LIU LI2   

  1. 1.The Third Tumor Hospital of Harbin Medical University,Harbin 150081;
    2.Heilongjiang University of Chinese Medicine,150040 Harbin
  • Received:2010-07-12 Online:2011-01-25 Published:2012-02-21

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Abstract:

Objective To observe the effect of ginsenoside Rg3(Shenyi capsule)on serum level of VEGF and treatment efficacy on NSCLC patients.Methods NSCLC patients who were in ⅢB and could not conduct operations were selected.In experiment group,patients have been treated by chemotherapy combined with ginsenoside Rg3 taken orally,20mg per time,twice a day and continuously for 2 courses of treatment.In control group,patients have been treated only by chemotherapy.After treatment were completed,patients serum levels of VEGF,CEA,quality of life,toxicity and adverse effect were observed.Results After treatment were completed,compared with control group,serum levels of VEGF and CEA decreased obviously(P＜0.05)in experiment group and patients quality of life were improved obviously(P＜0.05).The incidence of toxin and side effect in experiment group was obviously lower.Conclusion NSCLC patients who were in ⅢB and could not conduct operations accepting chemotherapy combined with ginsenoside Rg3 can inhibit tumor-related angiogenesis,increase the anti-tumor efficacy and improve the patients quality of life.

Key words: Ginsenoside Rg3, Non-small-cell lung cancer, VEGF

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