β-紫罗兰酮抗癌活性研究进展

doi:10.11904/j.issn.1002-3070.2021.03.014

Abstract

Abstract: Beta-ionone(BI)is a type of cyclized isoprene,widely distributed in fruits and vegetables.BI has a variety of biological activities,and its anti-cancer activity is a hot spot in current research.It can become a potential cancer chemopreventive agent.In order to better understand its effect on anti-tumor activity and its possible mechanism,this article briefly reviews the research progress in the effects of β-ionone on the activity of anti-tumor in recent years.

Key words: β-Ionone, Antitumor activity, Mechanism

CLC Number:

SHI Yuanyang, LIU Jiaren. Research progress in anticancer activity of β-ionone[J]. Journal of Practical Oncology, 2021, 35(3): 268-272.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.03.014

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I3/268

References

1 果思伽,刘家仁.植物化学物在癌症化学预防中的作用[J].实用肿瘤学杂志,2020,34(5):460-465.
2 Zhang H,Liu J,Li G,et al.Fresh red raspberry phytochemicals suppress the growth of hepatocellular carcinoma cells by PTEN/AKT pathway[J].Int J Biochem Cell Biol,2018,104:55-65.
3 常晓霞,宋冰冰,刘家仁.植物化学物增加肿瘤细胞对化疗药物敏感性的研究进展[J].实用肿瘤学杂志,2019,33(1):67-71.
4 Liu Q,Dong HW,Sun WG,et al.Apoptosis initiation of beta-ionone in SGC-7901 gastric carcinoma cancer cells via a PI3K-AKT pathway[J].Arch Toxicol,2013,87(3):481-490.
5 Liu JR,Chen BQ,Yang BF,et al.Apoptosis of human gastric adenocarcinoma cells induced by beta-ionone[J].World J Gastroenterol,2004,10(3):348-351.
6 Liu JR,Yang BF,Chen BQ,et al.Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and-2 expression[J].World J Gastroenterol,2004,10(2):167-171.
7 刘家仁,杨艳梅,董宏伟,等.β-紫罗兰酮对人乳腺癌细胞(Er-)MAPK途径的影响[J].卫生研究,2005,34(6):706-709.
8 Liu JR,Sun XR,Dong HW,et al.beta-Ionone suppresses mammary carcinogenesis,proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat[J].Int J Cancer,2008,122(12):2689-2698.
9 孙向荣,刘家仁,陈炳卿.b-紫罗兰酮的生物活性研究进展[J].毒理学杂志,2008,22(6):477-480.
10 Sharma V,Singh G,Kaur H,et al.Synthesis of beta-ionone derived chalcones as potent antimicrobial agents[J].Bioorg Med Chem Lett,2012,22(20):6343-6346.
11 De Moura Espindola R,Mazzantini RP,Ong TP,et al.Geranylgeraniol and beta-ionone inhibit hepatic preneoplastic lesions,cell proliferation,total plasma cholesterol and DNA damage during the initial phases of hepatocarcinogenesis,but only the former inhibits NF-kappaB activation[J].Carcinogenesis,2005,26(6):1091-1099.
12 刘家仁,李百祥,马若波,等.β-紫罗兰酮对人乳腺癌细胞抑制作用[J].卫生研究,2004,33(2):151-153.
13 董宏伟,王琪,金德利,等.β-紫罗兰酮诱导人乳腺癌细胞(ER+)凋亡作用[J].中国公共卫生,2015,31(2):193-195.
14 Dong HW,Zhang S,Sun WG,et al.beta-Ionone arrests cell cycle of gastric carcinoma cancer cells by a MAPK pathway[J].Arch Toxicol,2013,87(10):1797-808.
15 Kim MO,Moon DO,Kang CH,et al.beta-Ionone enhances TRAIL-induced apoptosis in hepatocellular carcinoma cells through Sp1-dependent upregulation of DR5 and downregulation of NF-kappaB activity[J].Mol Cancer Ther,2010,9(4):833-843.
16 Huang CS,Lyu SC,Hu ML.Synergistic effects of the combination of beta-ionone and sorafenib on metastasis of human hepatoma SK-Hep-1 cells[J].Invest New Drugs,2012,30(4):1449-1459.
17 Jones S,Fernandes NV,Yeganehjoo H,et al.beta-ionone induces cell cycle arrest and apoptosis in human prostate tumor cells[J].Nutr Cancer,2013,65(4):600-610.
18 Xie H,Liu T,Chen J,et al.Activation of PSGR with beta-ionone suppresses prostate cancer progression by blocking androgen receptor nuclear translocation[J].Cancer Lett,2019,453:193-205.
19 He L,Mo H,Hadisusilo S,et al.Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo[J].J Nutr,1997,127(5):668-674.
20 Mo H,Elson CE.Apoptosis and cell-cycle arrest in human and murine tumor cells are initiated by isoprenoids[J].J Nutr,1999,129(4):804-813.
21 Zhu J,Zhang L,Jin X,et al.beta-Ionone-induced apoptosis in human osteosarcoma(U2os)cells occurs via a p53-dependent signaling pathway[J].Mol Biol Rep,2010,37(6):2653-2663.
22 Cardozo MT,De Conti A,Ong TP,et al.Chemopreventive effects of beta-ionone and geraniol during rat hepatocarcinogenesis promotion:distinct actions on cell proliferation,apoptosis,HMGCoA reductase,and RhoA[J].J Nutr Biochem,2011,22(2):130-135.
23 Abd-Elbaset M,Mansour AM,Ahmed OM,et al.The potential chemotherapeutic effect of beta-ionone and/or sorafenib against hepatocellular carcinoma via its antioxidant effect,PPAR-gamma,FOXO-1,Ki-67,Bax,and Bcl-2 signaling pathways[J].Naunyn Schmiedebergs Arch Pharmacol,2020,393(9):1611-1624.
24 Asokkumar S,Naveenkumar C,Raghunandhakumar S,et al.Antiproliferative and antioxidant potential of beta-ionone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice[J].Mol Cell Biochem,2012,363(1-2):335-345.
25 Duncan RE,Lau D,El-Sohemy A,et al.Geraniol and beta-ionone inhibit proliferation,cell cycle progression,and cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells independent of effects on HMG-CoA reductase activity[J].Biochem Pharmacol,2004,68(9):1739-1747.
26 Dong HW,Wang K,Chang XX,et al.Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity[J].Arch Toxicol,2019,93(10):2993-3003.
27 Liu JR,Dong HW,Sun XR,et al.Effects of beta-ionone on mammary carcinogenesis and antioxidant status in rats treated with DMBA[J].Nutr Cancer,2010,62(1):58-65.
28 Hashemi Goradel N,Najafi M,Salehi E,et al.Cyclooxygenase-2 in cancer:a review[J].J Cell Physiol,2019,234(5):5683-5699.
29 刘家仁,陈炳卿,杨艳梅,等.β-紫罗兰酮抑制SGC-7901 细胞潜在的转移作用[J].卫生研究,2005,34(4):435-438.
30 Shaw RJ,Cantley LC.Ras,PI(3)K and mTOR signalling controls tumour cell growth[J].Nature,2006,441(7092):424-430.
31 Kholodenko BN,Birtwistle MR.Four-dimensional dynamics of MAPK information processing systems[J].Wiley Interdiscip Rev Syst Biol Med,2009,1(1):28-44.
32 Wang J,Weng J,Cai Y,et al.The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase[J].Prostate,2006,66(8):847-857.
33 Scolastici C,De Conti A,Cardozo MT,et al.beta-ionone inhibits persistent preneoplastic lesions during the early promotion phase of rat hepatocarcinogenesis:TGF-alpha,NF-kappaB,and p53 as cellular targets[J].Nutr Cancer,2014,66(2):234-241.
34 Ansari M,Emami S.beta-Ionone and its analogs as promising anticancer agents[J].Eur J Med Chem,2016,123:141-154.

[1]	YIN Qi, HU Yanjian, CUI Puze, HU Yanhua. Research progress of Notch signaling pathway in regulating apoptosis of tumor cells [J]. Journal of Practical Oncology, 2021, 35(2): 165-169.
[2]	YANG Siqi,SONG Qibin,LI Qingqing,YAO Yi. Research progress of targeted inhibition of FGFRs signal in the treatment of malignant tumors [J]. Journal of Practical Oncology, 2021, 35(1): 73-77.
[3]	DANG Yao,HUANG Fuhui,QIN Yixiao,CHE Qin,HAO Xiaolong,WANG Binquan. Research progress of metastatic mechanism and influencing factors of head and neck squamous cell carcinoma [J]. Journal of Practical Oncology, 2021, 35(1): 78-82.
[4]	HAN Jing, PU Yan, LIU Huibin. Effects of SKA1 on cell proliferation and apoptosis of renal cell carcinoma and its molecular mechanism [J]. Journal of Practical Oncology, 2020, 34(5): 404-411.
[5]	ZHANG Mengzhe, KANG Xiangdong. Research progress on the relationship between Krüpple-like transcription factor 4 and the development of colorectal cancer [J]. Journal of Practical Oncology, 2020, 34(5): 456-459.
[6]	CHEN Lantao, YAN We, LIU Jinglei, YAO Lei. Effect of tetrandrine on lung cancer H1299 cells and A549 cells and its molecular mechanism [J]. Journal of Practical Oncology, 2020, 34(2): 126-132.
[7]	LIU Guangxia, ZHAO Lianchun, CHEN Fang, JIA Qian, GAO Wei, HOU Zhan, LU Yamin. Effect and mechanism of ZCCHC12 on malignant transformation of thyroid cells [J]. Journal of Practical Oncology, 2020, 34(2): 133-138.
[8]	LIN Yuhua, NI Zhenhua, SUN Yipeng, BI Junjie, WANG Xiongbiao. Research progress on the relationship between SPDEF and malignant tumors [J]. Journal of Practical Oncology, 2020, 34(2): 185-188.
[9]	LI Yafei, ZHANG Xiao, WANG Xuefei, WENG Mingjiao, WANG Tianzhen. Effect of RNA-binding protein Lin28 on the development of malignant tumors and its molecular mechanism [J]. Journal of Practical Oncology, 2019, 33(5): 456-460.
[10]	CHANG Xiaoxia, SONG Bingbing, LIU Jiaren. Research progress in phytochemicals for increasing sensitivity of tumor cells to chemotherapies [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 67-72.
[11]	KAN Jun, ZHOU Daihan, ZHANG Enxin. Research progress in tumor with cardiovascular disease [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(6): 558-561.
[12]	WANG Yuan, SUN Yihua. Advance in the role of β-catenin in soft tissue tumors [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 455-459.
[13]	FAN Ningning, GENG Jingshu. The expression and role of LncRNA MEG3 in human glioma cells [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 219-223.
[14]	ZHANG Yongxin, HUANG He. Research progress and mechanism of Galectin-9 and various malignant tumors [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 159-163.
[15]	JIN Tuan, ZHANG Qingyuan. Research propress in signaling pathways and molecular mechanisms of brain metastases in breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2017, 31(5): 468-471.

Research progress in anticancer activity of β-ionone

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments