Journal of Practical Oncology ›› 2022, Vol. 36 ›› Issue (5): 445-451.doi: 10.11904/j.issn.1002-3070.2022.05.010

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Mechanisms of trastuzumab resistance and post-resistance treatment strategies in HER2-positive breast cancer

WANG Xinghan, LV Yalei   

  1. Department of Oncology,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China
  • Received:2022-03-29 Revised:2022-08-09 Online:2022-10-28 Published:2022-11-10

Abstract: Trastuzumab is effective in the treatment of human epidermal growth factor receptor 2(HER2)positive breast cancer,but the high drug resistance rate limits its clinical application.This article reviews and summarizes the mechanism of trastuzumab resistance in HER2-positive breast cancer,and analyzes the treatment strategies for HER2-positive breast cancer after drug resistance,in order to provide reference for further research and clinical treatment plan formulation.

Key words: Trastuzumab resistance, HER2-positive breast cancer, Mechanisms, Treatment

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