二甲双胍与多发性骨髓瘤的研究进展

doi:10.11904/j.issn.1002-3070.2020.05.017

Abstract

Abstract: Multiple myeloma(MM)is a malignant clonal plasma cell disease that originates in the bone marrow.It is mainly manifested by abnormal proliferation of monoclonal immunoglobulin,which is common in the elderly.New treatments for MM are emerging,but they are still incurable diseases.Therefore,it is particularly important to adopt new treatments to improve the prognosis of MM patients.In recent years,the anti-tumor effect of metformin has become a hot spot.In various basic studies,metformin has shown significant anti-cancer activity and can enhance the anti-tumor effects of other drugs.By the anti-tumor mechanism of metformin and the pathogenesis of MM,in this article,metformin may exert an anti-MM effect through the LKB1-AMPK-Akt/mTOR pathway,IGF receptor pathway,IL-6 signaling pathway,and the combined use of metformin with bortezomib,melphalan,dexamethasone and other drugs may enhance its treatment effects as a review,which will provide a new idea for the treatment of MM.

Key words: Multiple myeloma, Metformin, Pathogenesis, Drug treatment

CLC Number:

R733.3

ZHAO Yingxin, QIN Ling. Research progress of metformin and multiple myeloma[J]. Journal of Practical Oncology, 2020, 34(5): 476-479.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2020.05.017

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Research progress of metformin and multiple myeloma

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