Abstract: Objective The aim of this study was to analyze the trend of disease burden of prostate cancer in Jiangsu province from 1990 to 2019. Methods The disease burden of prostate cancer in Jiangsu province from 1990 to 2019 was analyzed using the 2019 Global Burden of Disease study on incidence,mortality,disability adjusted life years(DALY)rate,years lived with disability(YLD) and premature death-years of life lost(YLL)rate of prostate cancer in Jiangsu province.The annual percentage change(APC)and average annual percentage change(AAPC)of the age-standardized incidence,mortality,DALY rate,YLD rate and YLL rate by Chinese standard population of prostate cancer were calculated using Joinpoint software. Results From 1990 to 2019,the age-standardized incidence and YLD rate of prostate cancer in Jiangsu province showed an overall upward trend(AAPC were 2.10% and 3.20%,respectively,P＜0.05),and the age-standardized mortality,DALY rate and YLL rate showed a downward trend(AAPC were -0.42%,-0.48% and -0.69%,respectively,P＜0.05).The incidence and mortality of prostate cancer in Jiangsu province increased with age in 1990 and 2019,and the incidence and mortality were the highest in the ≥85-year-old group.The DALY,YLD and YLL of prostate cancer in the ≥85-year-old group all reached the highest values between 1990 and 2019. Conclusion From 1990 to 2019,the overall disease burden of prostate cancer in Jiangsu province tended to decrease,but the incidence level continued to rise,and disability burden caused by prostate cancer continued to increase.It is necessary to strengthen the prevention of prostate cancer.

Key words: Prostate cancer, Disease burden, Disability-adjusted life years, Jiangsu province