实用肿瘤学杂志 ›› 2016, Vol. 30 ›› Issue (1): 48-52.doi: 10.11904/j.issn.1002-3070.2016.01.010

• 综述 • 上一篇    下一篇

MicroRNA-7与肺癌关系的研究进展

陈艳艳, 廖娇 综述, 赵玉霞 审校   

  1. 中国医科大学附属第四医院放疗科(沈阳 110032)
  • 收稿日期:2015-07-31 出版日期:2016-02-28 发布日期:2016-02-25
  • 通讯作者: 赵玉霞,E-mail:zyx_yd@163.com
  • 作者简介:陈艳艳,女,(1985-),硕士研究生,从事肺癌放化疗的研究
  • 基金资助:
    辽宁省省直医院改革重点临床科室诊疗能力建设项目(LNCCC-B08-2014)

Progress in research on relationship between microRNA-7 and lung cancer

CHEN Yanyan, LIAO Jiao, ZHAO Yuxia   

  1. Department of Radiation Oncology of Cancer Centre,The Fouth Affiliated Hospital of China Medical University,Shenyang 110032,China
  • Received:2015-07-31 Online:2016-02-28 Published:2016-02-25

摘要: MicroRNA-7(miR-7)首先在果蝇(Drosophila melanogaster)体内被发现,参与果蝇翼、卵子等形成。在人类体内miR-7不但参与细胞增殖、分化等,还参与肿瘤的发生发展,尤其在肺癌中起重要作用。多数研究报道肺癌组织和肺癌细胞株中miR-7呈低表达,低表达组患者预后差,提高miR-7的表达能抑制肿瘤生长。miR-7作为肿瘤抑制因子,负性调控BCL-2、EGFR等的表达,调节肿瘤细胞对放化疗和靶向治疗的敏感性,有望成为肺癌治疗的新靶点。

关键词: MicroRNAs, miR-7, 肺肿瘤

Abstract: MicroRNA-7(miR-7)was firstly found in Drosophila melanogaster,which participated in the formation of Drosophila wings,eggs and so on.In human being miR-7 is not only involved in cell proliferation and differentiation,but also plays an important role in the development of tumor,especially in lung cancer.Most studies report that miR-7 is low expression in lung cancer with poor prognosis.Improving the expression of miR-7 can inhibit tumor growth.MiR-7 can regulate the expression of BCL-2,EGFR negatively,meanwhile it can regulate the sensitivity of tumor cells to radiotherapy chemotherapy and targeted therapy.Therefore,as a tumor suppressor,miR-7 is expected to become a new target for treatment of lung cancer.

Key words: MicroRNAs, miR-7, Lung cancer

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