MicroRNA-7与肺癌关系的研究进展

doi:10.11904/j.issn.1002-3070.2016.01.010

摘要/Abstract

摘要： MicroRNA-7(miR-7)首先在果蝇(Drosophila melanogaster)体内被发现,参与果蝇翼、卵子等形成。在人类体内miR-7不但参与细胞增殖、分化等,还参与肿瘤的发生发展,尤其在肺癌中起重要作用。多数研究报道肺癌组织和肺癌细胞株中miR-7呈低表达,低表达组患者预后差,提高miR-7的表达能抑制肿瘤生长。miR-7作为肿瘤抑制因子,负性调控BCL-2、EGFR等的表达,调节肿瘤细胞对放化疗和靶向治疗的敏感性,有望成为肺癌治疗的新靶点。

关键词: MicroRNAs, miR-7, 肺肿瘤

Abstract: MicroRNA-7(miR-7)was firstly found in Drosophila melanogaster,which participated in the formation of Drosophila wings,eggs and so on.In human being miR-7 is not only involved in cell proliferation and differentiation,but also plays an important role in the development of tumor,especially in lung cancer.Most studies report that miR-7 is low expression in lung cancer with poor prognosis.Improving the expression of miR-7 can inhibit tumor growth.MiR-7 can regulate the expression of BCL-2,EGFR negatively,meanwhile it can regulate the sensitivity of tumor cells to radiotherapy chemotherapy and targeted therapy.Therefore,as a tumor suppressor,miR-7 is expected to become a new target for treatment of lung cancer.

Key words: MicroRNAs, miR-7, Lung cancer

中图分类号:

R734.2

陈艳艳, 廖娇综述, 赵玉霞审校. MicroRNA-7与肺癌关系的研究进展[J]. 实用肿瘤学杂志, 2016, 30(1): 48-52.

CHEN Yanyan, LIAO Jiao, ZHAO Yuxia. Progress in research on relationship between microRNA-7 and lung cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(1): 48-52.

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