α-常春藤皂苷的抗肿瘤药理作用研究进展

doi:10.11904/j.issn.1002-3070.2019.06.015

实用肿瘤学杂志 ›› 2019, Vol. 33 ›› Issue (6): 553-556.doi: 10.11904/j.issn.1002-3070.2019.06.015

α-常春藤皂苷的抗肿瘤药理作用研究进展

许健, 詹月萍, 蒋元烨综述, 曹勤审校

上海中医药大学附属普陀医院(上海 200062)

收稿日期:2019-05-29 修回日期:2019-08-29 发布日期:2019-12-28
通讯作者: 曹勤,E-mail:caoqin434@sina.com
作者简介:许健,女,(1989-),硕士研究生,从事肠道微环境和胃肠道肿瘤方向的研究。
基金资助:
1.上海中医药大学附属普陀医院院级人才培养项目(编号:2017213A);2.上海中医药大学附属普陀医院重点专科(编号:2016103A);3.上海中医药大学附属普陀医院院级人才培养项目(编号:2016212B)

Advance in anti-tumor pharmacological action of α-hederin

XU Jian, ZHAN Yueping, JIANG Yuanye, CAO Qin

Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China

Received:2019-05-29 Revised:2019-08-29 Published:2019-12-28

摘要/Abstract

摘要： α-常春藤皂苷是从中药复方肠胃清中高压液相质谱分析所得的一个典型的五环三萜类皂苷,具有广泛的药理作用,如抗肿瘤、抗炎症反应和免疫调节等,其中最引人注目的是抗肿瘤作用。随着研究的不断深入,α-常春藤皂苷的抗肿瘤作用分子机制有一定突破,本文主要就近年来α-常春藤皂苷的抗肿瘤药理作用研究进展作简要综述,为今后研究和开发α-常春藤皂苷抗肿瘤作用提供依据。

关键词: α-常春藤皂苷, 抗肿瘤, 药理作用, 研究进展

Abstract: α-Hederin is a typical pentacyclic triterpenoid saponin obtained from high-pressure liquid phase mass spectrometry analysis of traditional Chinese medicine Changweiqing.It has a wide range of pharmacological effects,such as anti-tumor,anti-inflammatory and immune-modulation.The most striking of these pharmacological effects is the effect on anti-tumor.With the deepening of research,the molecular mechanism of α-hederin in effect on anti-tumor has made a certain breakthrough.This paper mainly summarizes the research progress of anti-tumor pharmacological action of α-hederin in recent years,and provides a basis for future research and development of α-hederin.

Key words: α-hederin, Anti-tumor, Pharmacological action, Advancement

中图分类号:

许健, 詹月萍, 蒋元烨, 曹勤. α-常春藤皂苷的抗肿瘤药理作用研究进展[J]. 实用肿瘤学杂志, 2019, 33(6): 553-556.

XU Jian, ZHAN Yueping, JIANG Yuanye, CAO Qin. Advance in anti-tumor pharmacological action of α-hederin[J]. Journal of Practical Oncology, 2019, 33(6): 553-556.

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α-常春藤皂苷的抗肿瘤药理作用研究进展

Advance in anti-tumor pharmacological action of α-hederin

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