MTBP与癌症的研究进展

doi:10.11904/j.issn.1002-3070.2016.06.017

Abstract

Abstract: MDM2-binding protein(MTBP)factor is a binding protein of MDM2,and MDM2 gene and involved in the development of cancer as an important gene,which has been studied for a long time.It has been demonstrated that MTBP could regulate biological processes such as metabolism,growth,and apoptosis of cells.In the past few years,some studies have found that MTBP is down-regulated in variety of malignancies,which is associated with the progression and the prognosis of these tumors.MTBP may be a potential target for the treatment of many kinds of malignant tumors.This paper reviews the research pregressof MDM2-binding protein on cancer.

Key words: MTBP, Cancer, Progress, Prognosis

CLC Number:

LI Genying,ZHANG Yunyan. Research progress of MDM2-binding protein in cancer[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(6): 560-562.

References

1 Ammer AG,Weed SA.Cortactin branches out:roles in regulating protrusive actin dynamics[J].Cell Motil Cytoskeleton,2008,65:687-707.
2 Boyd MT,Victrola N,Gaines DS.A novel cellular protein(MTBP)binds to MDM2 and induces a G1 arrest that is suppressed by MDM2[J].J Biol Chem,2000,275(41),31883-31890.
3 Umiak T,Loan G.MDM2 an introduction[J].Mol Cancer Res,2003,1(14):993-1000.
4 Vlatkovi＇c N,El-Fert A,Devling T,et al.Loss of MTBP expression is associated with reduced survival in a biomarker-defined subset of patients with squamous cell carcinoma of the head and neck[J].Cancer,2011,117(13):2939-2950.
5 Lu S,Zhou W,Wei H,et al.MTBP promotes the invasion and metastasis of hepatocellular carcinoma by enhancing the MDM2-mediated degradation of E-cadherin[J].Dig Dis Sci,2015,60(12):3681-3690.
6 Grieb BC,Chen X,Eischen CM,et al.MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival[J].Mol Cancer Res,2014,12(9):1216-1224.
7 Seong BK,Lau J,Adderley T,et al.SATB2 enhances migrate on and invasion in osteosarcoma by regulating genes involved in cytoskeletal organization[J].Oncogene,2015,34(27):3582-3592.
8 Boyd MT,Zimonjic DB,Popescu NC,et al.Assignment of the MDM2 binding protein gene(MTBP)to human chromosome band 8q24 by in situ hybridization[J].Cytogenet Cell Genet,2000,90(1/2):64-65.
9 Agarwal N,Tochigi Y,Adhikari AS,et al.MTBP plays a crucial role in mitotic progression and chromosome segregation[J].Cell Death Differ,2011,18(7):1208-1219.
10 Odvody J,Vincent T,Arrate MP,et al.A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis[J].Oncogene,2010,29(22):3287-3296.
11 Chen X,Xu Z,Wang Y,et al.Recent advances in breast cancer metastasis suppressor[J].Int J Biol Markers,2011,26(1):1-8.
12 Agarwal N,Adhikari AS,Iyer SV,et al.MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4[J].Oncogene,2013,32(4):462-470.
13 Lemaire F,Millon R,Young J,et al.Differential expression profiling of head and neck squamous cell carcinoma(HNSCC)[J].Br J Cancer,2003,89:1940-1949.
14 khan AM,Tomkinson A.Head & neck cancer incidence in Wales 1992-2001[J].Clin Otolaryngol,2006,31:247-248.
15 Wei KR,Yu X,Zheng RS,et al.Incidence and mortality of liver cancer in China[J].Chin J Cancer,2014,33(8):388-394.
16 Bi Q,Ranjan A,Ranjan A,et al.MTBP inhibits migration and metastasis of hepatocellular carcinoma[J].Clin Exp Metastasis,2015,32(4):301-311.
17 Siegel RL,Miller KD,Jemal A,et al.Cancer statistics,2015[J].CA Cancer J Clin,2015,65:5-29.
18 Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China[J].Lancet Oncol,2014,15:279-289.
19 Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2015[J].CA Cancer J Clin,2015,65(2):87-108.
20 Iwakuma T,Tochigi Y,Van Pelt CS,et al.MTBP haploinsufficiency in mice increases tumor metastasis[J].Oncogene,2008,27(13):1813-1820.

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Research progress of MDM2-binding protein in cancer

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