PRACTICAL ONCOLOGY JOURNAL ›› 2013, Vol. 27 ›› Issue (2): 116-119.doi: 10.3969/j.issn.1002-3070.2013.02.005

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Experimental study of phenolic alkaloids of menispermum dauricum on proliferation of human gastric cancer cell line SGC-7901

ZHANG Hongfeng1,ZHANG Yan2,SU Hui2   

  1. 1.The Affiliated Tumor Hospital of Harbin Medical University,Harbin 150040,China;
    2.Heilongjiang University of Chinese Medicine
  • Received:2013-01-04 Online:2013-04-28 Published:2013-04-26

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Abstract: Objective To determine the effect of phenolic alkaloids of menispermum dauricum on the gastric cancer cell SGC-7901 proliferation.Methods We studied the effect of phenolic alkaloids of menispermum at different concentrations and different times on the gastric cancer cell SGC-7901 proliferation by MTT and trypan blue methods.Results PAMD can obviously inhibit SGC-7901 cell proliferation,and is dose-and time-dependent relationship with extended periods of concentration increase.Its role and inhibition rate was on the rise.Conclusion PAMD may have some therapeutic effect on gastric cancer.

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