GATA4对肿瘤影响的研究进展

doi:10.11904/j.issn.1002-3070.2025.04.012

Abstract

Abstract: GATA binding proteins are a family of transcription factors that play crucial roles in normal human growth and development.GATA4,one of the members of the GATA family,has received increasing attention due to its ability to regulate the biological activities of various types of tumor cells.This article provides an overview of the biological mechanisms of GATA4 expression in different types of tumors and the effects of methylation modifications on GATA4 expression.It further explores the interactions between GATA4 and other signaling pathways,as well as its impact on the tumor microenvironment,demonstrating its enormous potential as tumor biomarker and therapeutic target.The aim is to provide a reference for further research of GATA4′s mechanism of action and epigenetic regulation in the tumor development,to lay a theoretical foundation for exploring the potential application of GATA4 as a tumor diagnostic biomarker or targeted therapy strategy.

Key words: Transcription factors, GATA binding protein 4, Methylation, Tumor, Signaling pathways

CLC Number:

LI Xiaotong, MIAO Miao, HOU Kaijiong, CHEN Hong. Research progress in the impact of GATA4 on tumors[J]. Journal of Practical Oncology, 2025, 39(4): 338-342.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2025.04.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2025/V39/I4/338

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Research progress in the impact of GATA4 on tumors

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