Abstract: Objective To compare the short-term tumor response and adverse events of two chemoradiotherapy regimens for locally advanced non-squamous non-small cell lung cancer.Methods From March 2009 to January 2013,we recruited 42 patients with stage Ⅲ NSCLC who had received three-dimensional intensity-modulated radiotherapy combined with chemotherapy.group A treated with radiotherapy combined pemetrexed plus cisplatin and group B treated with radiotherapy combined docetaxel plus cisplatin.We compared the short-term tumor response and adverse events between the two regimens.Results There were 28 cases in group A and 14 cases in group B.There were no significant differences between the two groups in hematologic toxicities,such as leukopenia,neutropenia,anemia and thrombocytopenia.In non-hematologic toxicities,radiation pneumonitis and cough were no significances respectively(P＜0.05).There were no significant differences in other non-hematologic toxicities,such as liver dysfunction,renal dysfunction,fever,dyspnea,radiation esophagitis,hypodynamia,weight loss,gastrointestinal reactions and skin reactions.The response rate displayed no differences between two groups.Conclusion This study reveals Pemetrexed plus cisplatin group had less non-hematologic toxicities than Docetaxel plus cisplatin group in locally advanced non-squamous non-small cell lung cancer.But there are no differences in the short-term tumor response between the two regimens.