Abstract:

Objective To evaluate the expression and clinical significance of A disintegrin and metalloproteinase(ADAM-19),Ki-67 in early invasive cervical cancer.Methods Expression of ADAM-19 and Ki-67 in 18 cases of normal cervical epithelium(NCE),22 cases of cervical intraepithelial neoplasm(CIN) and 82 cases of invasive carcinoma cervix(ICC)were detected by immunohistochemistry SP method.Results ADAM-19 was mainly expressed in the cellular membrane and/or cytoplasm in tumor cells,whereas the expression of Ki-67 was localized within the nuclei.It was demonstrated that positive rate of expression of ADAM-19 increased remarkably from normal cervical epithelium(NCE)to cervical intraepithelial neoplasm(CIN),and then to invasive carcinoma cervix(ICC)accordingly(P＜0.05).In ICC,the expression of ADAM-19 correlated with pelvic lymph node metastasis,intravascular and stromal infiltration,FIGO staging,histological grading and Ki-67 expression(P＜0.05);but not correlated with patients age and histological types(P＞0.05).In cases with pelvic lymph node metastasis,intravascular and deeper stroma infiltration,FIGO staging II and histological grading III over-expression of Ki-67,positive rate of ADAM-19 was significantly higher than that in those without the conditions mentioned above(P＜0.05).Conclution In cervical cancer,ADAM-19 may play an important role during proliferation of tumor cells,carcinoma invasion and metastasis.Over-expression of ADAM-19 may increase the proliferation of tumor cells and cancer progression,but it is not the only decisive factor.Early detection of ADAM-19 may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma.

Key words: Cervical cancer, ADAM-19, Ki-67