PRACTICAL ONCOLOGY JOURNAL ›› 2015, Vol. 29 ›› Issue (1): 39-43.doi: 10.11904/j.issn.1002-3070.2015.01.008

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Metadherin promotes gastric carcinoma metastasis through induction of epithelial-mesenchymal transition

XIA Lin1,YU Guozheng2,ZENG Xiantao3,LI Sheng3,BING Yuntao2,LI Ting2,YANG Guifang4   

  1. 1.Department of Medical Oncology,Puai Area,Huangshi Central Hospital,Huangshi 435000,China;
    2.Department of General Surgery,Zhongnan Hospital,Wuhan University;
    3.Center for Evidence-Based and Translational Medicine Zhongnan Hospital,Wuhan University;
    4.Department of Pathology,Zhongnan Hospital,Wuhan University
  • Received:2014-09-05 Online:2015-02-28 Published:2015-03-06

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Abstract: Objective To explore the relationship between gene MTDH expression and its role in promoting gastric carcinoma metastasis.Methods We collected clinical specimens and cultured gastric carcinoma cell lines.By Western blotting and Real-time PCR methods,protein and mRNA levels in tissues and MTDH relationship with EMT were detected.Results There was 86% of patients who expressed MTDH positively and 13% of normal gastric mucosa was positive expression.The Results showed that the expressive level of MTDH gene in gastric carcinoma was higher than in the normal tissues.The expression of MTDH was correlated with TNM stage、microvascular invasion、recurrence and metastasis.The expressive level of MTDH was correlated with two epithelial mesenchymal transition markers(E-cadherin and N-cadherin).Conclusion MTDH may promote gastric carcinoma metastasis through the induction of EMT process and may be a candidate biomarker for therapeutic target.

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