Abstract: Objective To analyze the clinic pathologic factors and survival rate by performing a retrospective study on the early gastric carcinoma(EGC)with signet ring cell underwent curative gastrostomy(SRC)percentage less than 50% after operation.Methods A total of 424 patients was diagnosed as EGC from January 2008 to January 2010 in Changhai Hospital.The patients were divided into three groups according to the different percentage of SRC within tumor cells,SRC group(with percentage of SCR more than 50%),Mixed SRC group(with percentage of SRC less than 50%),and Non-SRC group(Classic adenocarcinoma without SRC).Then we evaluated the clinic pathologic indicators and prognoses,and study on the relationship with histologic types.Results In ECG,the mixed-SRC group was similar to the SRC group on the phases of onset age and sex.On the other phases,the mixed-SRC group was more associated with mucosa-confined,lower lymph node metastasis(LNM),and 5-year survival rate was better than adenocarcinoma group(P＜0.05).However,the mixed-SRC group showed more submucosal invasion,and higher LNM than other groups(P＜0.05).The mixed-SRC component was one of the independent risk factors of LNM.Conclusion In EGC,mixed-SRC had a more favorable risk factor of LNM,showed more aggressive behavior than other groups and displayed poor prognosis.

Key words: Clinicopathological characteristics, Early gastric carcinoma, Signet ring cell carcinoma