类固醇激素在乳腺癌中的作用及对肿瘤干细胞的影响

doi:10.11904/j.issn.1002-3070.2019.05.016

Abstract

Abstract: Steroid hormones,especially estrogens and progestins,play an important role in the pathogenesis,progression and treatment of breast cancer.At the same time,a large number of studies have confirmed that cancer stem cells also play a key role in the occurrence,progression and metastasis of breast cancer.In preclinical models of breast cancer,although tumor cells have been significantly inhibited by conventional anti-endocrine therapy,only a small number of breast cancer stem cells(BCSCs)are needed to maintain tumor re-growth.In the past,a large number of studies have focused on the relationship between hormones in the development of normal breast and breast cancer.Recently,many studies have examined effects of hormones on the activity of breast cancer stem cell,which has opened up a new research direction for breast cancer treatment and CSCs.This paper comprehensively discusses the role of steroid hormones(estrogen and progesterone)in breast cancer and their regulation of breast BCSCs.

Key words: Breast cancer, Cancer stem cells, Estrogen, Progesterone

CLC Number:

R730.43

WANG Yu, QIAO Juanjuan, ZHANG Lei, LIU Siwei, YANG Shucai. The role of steroid hormones in breast cancer and its effect on cancer stem cells[J]. Journal of Practical Oncology, 2019, 33(5): 466-470.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2019.05.016

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2019/V33/I5/466

References

1 Collina F,Bonito MD,Bergolis VL,et al.Prognostic value of cancer stem cells markers in triple-negative breast cancer[J].Biomed Res Int,2016,2015(4):1-10.
2 陈明慧,陈喜杰,王艳.CD44v6与非小细胞肺癌的研究进展[J].实用肿瘤学杂志,2016,30(2):172-175.
3 Basakran NS.CD44 as a potential diagnostic tumor marker[J].Saudi Med J,2015,36(3):273-279.
4 Charafe-Jauffret E,Ginestier C,Iovino F,et al.Aldehyde dehydrogenase1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer[J].Clin Cancer Res,2010,16(1):45-55.
5 Liu S,Cong Y,Wang D,et al.Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts[J].Stem Cell Reports,2014,2(1):78-91.
6 Arendt LM,Kuperwasser C.Form and function:how estrogen and progesterone regulate the mammary epithelial hierarchy[J].J Mammary Gland Biol Neoplasia,2015,20(1/2):9-25.
7 Carroll JS,Liu XS,Brodsky AS,et al.Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1[J].Cell,2005,122(1):33-43.
8 Clemons M,Goss P.Estrogen and the risk of breast cancer[J].N Engl J Med,2001,344(4):276-285.
9 Simoes BM,O'Brien CS,Eyre R,et al.Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity[J].Cell Rep,2015,12(12):1968-1977.
10 Huang ZJ,You J,Luo WY,et al.Reduced tumorigenicity and drug resistance through the downregulation of octamer-binding protein 4 and Nanog transcriptional factor expression in human breast stem cells[J].Mol Med Rep,2015,11(3):1647-1654.
11 Kurebayashi J,Kanomata N,Yamashita T,et al.Antitumor and anticancer stem cell activities of eribulin mesylate and antiestrogens in breast cancer cells[J].Breast,2015,24(3):425-436.
12 Axlund SD,Yoo BH,Rosen RB,et al.Progesterone-inducible cytokeratin 5-positive cells in luminal breast cancer exhibit progenitor properties[J].Horm Cancer,2013,4(1):36-49.
13 Zhou X,Wang S,Wang Z,et al.Estrogen regulates Hippo signaling via GPER in breast cancer[J].J Clin Invest,2015,125(5):2123-2135.
14 Cordenonsi M,Zanconato F,Azzolin L,et al.The hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells[J].Cell,2011,147(4):759-772.
15 Amabile M,De Smet R,Moriconi C,et al.TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells[J].Oncogene,2014,34(6):681-690.
16 Deng H,Zhang XT,Wang ML,et al.ER-alpha36-mediated rapid estrogen signaling positively regulates ER-positive breast cancer stem/progenitor cells[J].PLoS One,2014,9(2):e88034.
17 Gelsomino L,Panza S,Giordano C,et al.Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through Notch activation in breast cancer cell lines[J].Cancer Lett,2018,428:12-20.
18 Deng H,Yin L,Zhang XT,et al.ER-alpha variant ER-alpha36 mediates antiestrogen resistance in ER-positive breast cancer stem/progenitor cells[J].J Steroid Biochem Mol Biol,2014,144:417-426.
19 Kang L,Guo Y,Zhang X,et al.A positive cross-regulation of HER2 and ER-alpha36 controls ALDH1 positive breast cancer cells[J].J Steroid Biochem Mol Biol,2011,127(3-5):262-268.
20 Ma R,Karthik GM,John Lövrot J,et al.Estrogen receptor β as a therapeutic target in breast cancer stem cells[J].J Natl Cancer Inst,2017,109(3):1-14.
21 Lawson DA,Bhakta NR,Kessenbrock K,et al.Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells[J].Nature,2015,526(7571):131-135.
22 Jameera BA,Jubie S,Nanjan MJ.Estrogen receptor agonists/antagonists in breast cancer therapy:A critical review[J].Bioorg Chem,2017,71:257-274.
23 Creighton CJ,Li X,Landis M,et al.Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features[J].Proc Natl Acad Sci U S A,2009,106(33):13820-13825.
24 Shea MP,O′Leary KA,Fakhraldeen SA,et al.Anti-estrogen therapy increases plasticity and cancer stemness of prolactin-induced ERα+ mammary carcinomas[J].Cancer Res,2018,78(7):1672-1684.
25 Sansone P,Berishaj M,Rajasekhar VK,et al.Evolution of cancer stem-like cells in endocrine-resistant metastatic breast cancers is mediated by stromal microvesicles[J].Cancer Res,2017,77(19):5438.
26 Carlini MJ,Recouvreux MS,Simian M,et al.Gene expression profile and cancer-associated pathways linked to progesterone receptor isoform a(PRA)predominance in transgenic mouse mammary glands[J].BMC Cancer,2018,18(1):682.
27 Boonyaratanakornkit V,Hamilton N,MárquezGarbán DC,et al.Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer[J].Mol Cell Endocrinol,2017,466:51-72.
28 Joshi PA,Jackson HW,Beristain AG,et al.Progesterone induces adult mammary stem cell expansion[J].Nature,2010,465(7299):803-807.
29 Goyette S,Liang Y,Mafuvadze B,et al.Natural and synthetic progestins enrich cancer stem cell-like cells in hormone-responsive human breast cancer cell populations in vitro[J].Breast Cancer,2017,9:347-357.
30 Schramek D,Leibbrandt A,Sigl V,et al.Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer[J].Nature,2010,468(7320):98-102.
31 Beral V,Reeves G,Bull D,et al.Breast cancer risk in relation to the interval between menopause and starting hormone therapy[J].J Natl Cancer Inst,2011,22(4):360-362.
32 Wood CE,Branstetter D,Jacob AP,et al.Progestin effects on cell proliferation pathways in the postmenopausal mammary gland.Breast Cancer Res[J].2013,15(4):62.
33 Azam S,Lange T,Huynh S,et al.Hormone replacement therapy,mammographic density,and breast cancer risk:a cohort study[J].Cancer Causes Control,2018,29(6):495-505.
34 Fettig LM,Mcginn O,Finlayschultz J,et al.Cross talk between progesterone receptors and retinoic acid receptors in regulation of cytokeratin 5-positive breast cancer cells[J].Oncogene,2017,36(44):6074-6084.
35 Howe EN.Progestin suppression of miR-29 potentiates dedifferentiation of breast cancer cells via KLF4[J].Oncogene,2013,32(20):2555-2564.
36 Shiah YJ,Tharmapalan P,Casey AE,et al.A progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland[J].Stem Cell Reports,2015,4(3):313-322.
37 Finlay-Schultz J,Cittelly DM,Hendricks P,et al.Progesterone downregulation of miR-141 contributes to expansion of stem-like breast cancer cells through maintenance of progesterone receptor and STAT5a[J].Oncogene,2015,34(28):3676-3687.
38 Zhang P,Andrianakos R,Yang Y,et al.Kruppel-like factor 4(Klf4)prevents embryonic stem(ES)cell differentiation by regulating Nanog gene expression[J].J Biol Chem,2010,285(12):9180-9189.
39 Reichenstein M,Rauner G,Kfir S,et al.Luminal STAT5 mediates H2AX promoter activity in distinct population of basal mammary epithelial cells[J].Oncotarget,2016,7(27):41781-41797.
40 Hurtz C,Hatzi K,Cerchietti L,et al.BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia[J].J Exp Med,2011,208(11):2163-2174.
41 Goodman CR,Sato T,Peck AR,et al.Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism[J].Oncogene,2016,35(11):1373-1385.
42 Alfakeeh A,Brezdenmasley C.Overcoming endocrine resistance in hormone receptor-positive breast cancer[J].Current Oncology,2018,25(Suppl 1):18.
43 Esber N,Cherbonnier C,Resche-Rigon M,et al.Anti-tumoral effects of anti-progestins in a patient-derived breast cancer xenograft model[J].Horm Cancer,2016,7(2):137-147.
44 Mohammed H,Russell IA,Stark R,et al.Progesterone receptor modulates ERalpha action in breast cancer[J].Nature,2015,523(7560):313-317.

[1]	SHI Manru, E Mingyan. Effect of delayed radiotherapy on the prognosis of patients with different molecular subtypes of breast cancer [J]. Journal of Practical Oncology, 2019, 33(5): 431-435.
[2]	LI Lei, ZHANG Qingyuan. Clinical progress of anti-tumor vascular therapy for breast cancer [J]. Journal of Practical Oncology, 2019, 33(5): 461-465.
[3]	LIU Eryu, YANG Hao, LIANG Guohua, ZHAO Yanfang, ZHAO Wenhui. Action for CDK4/6 inhibitors combined with mTOR inhibitors in breast cancer and its mechanism [J]. Journal of Practical Oncology, 2019, 33(5): 476-480.
[4]	AN Weiwei, TANG Yali, ZHAO Lianhua, YANG Yue, WANG Xinling. Polyphenylene-polysaccharide complex from pinus koraiensis extract induces apoptosis in human breast cancer MCF-7 cells [J]. Journal of Practical Oncology, 2019, 33(4): 289-293.
[5]	HU Lin, SHEN Jia. Growth differentiation factor 15 plays a role in predicting and monitoring the cardiotoxicity of epirubicin/cyclophosphamide-docetaxel-trastuzumab in the treatment of patients with HER-2 positive breast cancer [J]. Journal of Practical Oncology, 2019, 33(4): 340-345.
[6]	MA Yan, HE Hong, WANG Sainan. Clinical study of docetaxel in the treatment of metastatic breast cancer in different age groups [J]. Journal of Practical Oncology, 2019, 33(4): 352-356.
[7]	WANG Xiaoya,XIAO Bin,LIAO Yang,TANG Rongzhi,SUN Zhaohui,LI Linhai. Expression of CXCR family proteins in different subtypes of breast cancer and their clinical prognosis [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 206-210.
[8]	LI Shuo,ZHANG Nannan,LI Liangliang,LONG Zhiping,YIN Huihui,ZHAO Yashuang,WANG Fan. Relationship between PDE4C gene methylation in peripheral blood leukocytes,interaction of environmental factors and pathogenesis of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(3): 233-238.
[9]	CHEN Yanbo, KONG Dejia, ZHANG Jinfeng, MA Zhigang. Correlation between CYP2D6 gene polymorphism and tamoxifen metabolism in breast cancer patients [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 110-114.
[10]	SUN Jianghong, HAO Mingzhu, JIANG Dan, GUO Fei, LI Xiaomei. FFDM differential diagnosis of mastitis,benign hyperplasia and breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 139-141.
[11]	MA Zhijie, WANG Fan, ZHAO Yashuang. Analysis of life quality and influencing factors in breast cancer patients with chemotherapy [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(2): 149-154.
[12]	MA Zhingying, SHANG Naijian, CAI Miaotian, SHEN Yang, JIANG Zhiyun. Correlation between HER-2 receptor of progesterone and estrogen receptor-positive breast cancer and mammography imaging & clinicopathological features [J]. PRACTICAL ONCOLOGY JOURNAL, 2019, 33(1): 47-51.
[13]	HE Xu, YE shangmian, DONG dandan, LI Ke. The expression of HLA-G in breast cancer and its significance [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(5): 410-414.
[14]	LIN Rongjie, YIN Hang, ZHOU Yunfeng. Effect of ON123300 on ER+ human breast cancer MCF-7 cells and its mechanism [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 193-197.
[15]	LI Lin, LI Zhigao. The relationship between metformin and different molecular subtypes of breast cancer [J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(3): 267-270.

The role of steroid hormones in breast cancer and its effect on cancer stem cells

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments