Jagged1促进乳腺癌发生发展及远处转移的研究进展

doi:10.11904/j.issn.1002-3070.2021.05.012

Abstract

Abstract: Breast cancer is a disease that seriously endangers women's physical and mental health.The death of patients with advanced breast cancer is largely due to distant metastasis of important organs rather than primary tumors.Jagged1(JAG1),as one of the important ligands of the Notch signaling pathway,is not only expressed in tumor cells but also expressed in cells in the tumor microenvironment.By activating the Notch signaling pathway,it promotes the aggressive progression and distant metastasis of breast cancer.This paper comprehensively discusses the location of the JAG1 gene and the structure of the JAG1 protein,the mechanism of JAG1 promoting distant metastasis of breast cancer,the mechanisms of JAG1 promoting breast cancer distant metastasis,brain metastasis,and bone metastasis as well as JAG1 targeted therapy.

Key words: Jagged1(JAG1), Breast cancer, Distant metastasis, Targeted therapy

CLC Number:

R737.9

MA Buhuan¹, LIU Caixia². Research progress of Jagged1 promoting the occurrence,development and distant metastasis of breast cancer[J]. Journal of Practical Oncology, 2021, 35(5): 452-457.

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URL: http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/10.11904/j.issn.1002-3070.2021.05.012

http://journal09.magtechjournal.com/Jwk3_syzlxzz/EN/Y2021/V35/I5/452

References

1 Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021[Online ahead of print].
2 Wu Y,Shao A,Wang L,et al.The role of lncRNAs in the distant metastasis of breast cancer[J].Front Oncol,2019,9:407.
3 Xing F,Kobayashi A,Okuda H,et al.Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain[J].EMBO Mol Med,2013,5(3):384-396.
4 Sethi N,Dai X,Winter CG,et al.Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells[J].Cancer Cell,2011,19(2):192-205.
5 Krishna BM,Jana S,Singhal J,et al.Notch signaling in breast cancer:from pathway analysis to therapy[J].Cancer Lett,2019,461:123-131.
6 Grochowski CM,Loomes KM,Spinner NB.Jagged1(JAG1):Structure,expression,and disease associations[J].Gene,2016,576(1 Pt 3):381-384.
7 Li D,Masiero M,Banham AH,et al.The notch ligand JAGGED1 as a target for anti-tumor therapy[J].Front Oncol,2014,4:254.
8 袁磊,李伯和,时冉冉,等.沉默JAG1基因对人乳腺癌MDA-MB-231细胞增殖和凋亡的影响[J].中国病理生理杂志,2014,30(2):262-267.
9 Zheng H,Bae Y,Kasimir-Bauer S,et al.Therapeutic antibody targeting tumor-and osteoblastic Niche-Derived Jagged1 sensitizes bone metastasis to chemotherapy[J].Cancer Cell,2017,32(6):731-747.
10 Masiero M,Li D,Whiteman P,et al.Development of therapeutic anti-JAGGED1 antibodies for cancer therapy[J].Mol Cancer Ther,2019,18(11):2030-2042.
11 Simoes BM,O'Brien CS,Eyre R,et al.Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity[J].Cell Rep,2015,12(12):1968-1977.
12 Shah D,Wyatt D,Baker AT,et al.Inhibition of HER2 increases JAGGED1-dependent breast cancer stem cells:role for membrane JAGGED1[J].Clin Cancer Res,2018,24(18):4566-4578.
13 Shao S,Zhao X,Zhang X,et al.Notch1 signaling regulates the epithelial-mesenchymal transition and invasion of breast cancer in a Slug-dependent manner[J].Mol Cancer,2015,14:28.
14 Chen J,Imanaka N,Chen J,et al.Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion[J].Br J Cancer,2010,102(2):351-360.
15 Leong KG,Niessen K,Kulic I,et al.Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin[J].J Exp Med,2007,204(12):2935-2948.
16 Wan L,Pantel K,Kang Y.Tumor metastasis:moving new biological insights into the clinic[J].Nat Med,2013,19(11):1450-1464.
17 Mahmood N,Mihalcioiu C,Rabbani SA.Multifaceted role of the urokinase-type Plasminogen Activator(uPA)and its Receptor(uPAR):diagnostic,prognostic,and therapeutic applications[J].Front Oncol,2018,8:24.
18 Shimizu M,Cohen B,Goldvasser P,et al.Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer[J].Cancer Res,2011,71(1):277-286.
19 Gerhardt H,Golding M,Fruttiger M,et al.VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia[J].J Cell Biol,2003,161(6):1163-1177.
20 Benedito R,Roca C,Sorensen I,et al.The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis[J].Cell,2009,137(6):1124-1135.
21 Williams CK,Li JL,Murga M,et al.Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function[J].Blood,2006,107(3):931-939.
22 Hellstrom M,Phng LK,Hofmann JJ,et al.Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis[J].Nature,2007,445(7129):776-780.
23 Pedrosa AR,Trindade A,Fernandes AC,et al.Endothelial Jagged1 antagonizes Dll4 regulation of endothelial branching and promotes vascular maturation downstream of Dll4/Notch1[J].Arterioscler Thromb Vasc Biol,2015,35(5):1134-1146.
24 High FA,Lu MM,Pear WS,et al.Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development[J].Proc Natl Acad Sci U S A,2008,105(6):1955-1959.
25 Scheppke L,Murphy EA,Zarpellon A,et al.Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane[J].Blood,2012,119(9):2149-2158.
26 Thurston G,Noguera-Troise I,Yancopoulos GD.The Delta paradox:DLL4 blockade leads to more tumour vessels but less tumour growth[J].Nat Rev Cancer,2007,7(5):327-331.
27 Trindade A,Duarte A.Notch signaling function in the angiocrine regulation of tumor development[J].Cells,2020,9(11):2467.
28 Jiang H,Zhou C,Zhang Z,et al.Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1[J].Nat Commun,2020,11(1):5129.
29 Lu J,Ye X,Fan F,et al.Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1[J].Cancer Cell,2013,23(2):171-185.
30 Xu K,Usary J,Kousis PC,et al.Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer[J].Cancer Cell,2012,21(5):626-641.
31 Morel AP,Ginestier C,Pommier RM,et al.A stemness-related ZEB1-MSRB3 axis governs cellular pliancy and breast cancer genome stability[J].Nat Med,2017,23(5):568-578.
32 Liu H,Wang J,Zhang M,et al.Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients[J].Breast Cancer Res Treat,2017,166(1):95-107.
33 Tang X.Tumor-associated macrophages as potential diagnostic and prognostic biomarkers in breast cancer[J].Cancer Lett,2013,332(1):3-10.
34 Pandya K,Wyatt D,Gallagher B,et al.PKCalpha attenuates Jagged-1-mediated Notch signaling in ErbB-2-positive breast cancer to reverse Trastuzumab resistance[J].Clcin Cancer Res,2016,22(1):175-186.
35 Tabouret E,Chinot O,Metellus P,et al.Recent trends in epidemiology of brain metastases:an overview[J].Anticancer Res,2012,32(11):4655-4662.
36 Custodio-Santos T,Videira M,Brito MA.Brain metastasization of breast cancer[J].Biochim Biophys Acta Rev Cancer,2017,1868(1):132-147.
37 Lin Q,Balasubramanian K,Fan D,et al.Reactive astrocytes protect melanoma cells from chemotherapy by sequestering intracellular calcium through gap junction communication channels[J].Neoplasia,2010,12(9):748-754.
38 Steg AD,Katre AA,Goodman B,et al.Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer[J].Clin Cancer Res,2011,17(17):5674-5685.
39 Tan Y,Peng J,Wei D,et al.Effect of Jagged1 on the proliferation and migration of colon cancer cells[J].Exp Ther Med,2012,4(1):89-92.
40 Zhang J,Li N,Lu S,et al.The role of Notch ligand Jagged1 in osteosarcoma proliferation,metastasis,and recurrence[J].J Orthop Surg Res,2021,16(1):226.
41 Xiu MX,Liu YM,Kuang BH.The oncogenic role of Jagged1/Notch signaling in cancer[J].Biomed Pharmacother,2020,129:110416.
42 Teider N,Scott DK,Neiss A,et al.Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma[J].Neuro Oncol,2010,12(12):1244-1256.
43 Hu W,Liu T,Ivan C,et al.Notch3 pathway alterations in ovarian cancer[J].Cancer Res,2014,74(12):3282-3293.
44 Kerr DJ,Young AM.Targeted therapies:bevacizumab--has it reached its final resting place?[J].Nat Rev Clin Oncol,2011,8(4):195-196.
45 Bergers G,Hanahan D.Modes of resistance to anti-angiogenic therapy[J].Nat Rev Cancer,2008,8(8):592-603.
46 Takebe N,Nguyen D,Yang SX.Targeting notch signaling pathway in cancer:clinical development advances and challenges[J].Pharmacol Ther,2014,141(2):140-149.

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Research progress of Jagged1 promoting the occurrence,development and distant metastasis of breast cancer

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