NQO1高表达提示宫颈癌预后不良

doi:10.11904/j.issn.1002-3070.2016.04.012

Abstract

Abstract: Objective To investigate the clinicopathological significance of upregulated NQO1 protein expression in uterine cervix carcinoma(UCC).Methods Immunohistochemical staining was performed on paraffin-embedded UCC specimens from 123 patients.Disease-free survival(DFS)and overall survival(OS)rates for all cervical UCC patients were calculated using the Kaplan-Meier method,and univariate or multivariate analyses were performed using the Cox proportional hazards regression model.Results The NQO1 protein showed a mainly cytoplasmic staining pattern in cervical cancer cells,and the strongly positive rate of NQO1 was significantly higher in UCC.High-level NQO1 was closely associated with poor differentiation,late-stage,lymph node metastasis and high-risk for HPV infection.Additionally,high-level NQO1 was associated with lower DFS and OS rates.Furthermore,Cox analysis revealed that NQO1 expression emerged as a significant independent hazard factor for DFS rate in patients with UCC.Conclusion NQO1 overexpression might be an independent biomarker for prognostic evaluation of UCCs.

Key words: Uterine cervix carcinoma, NQO1, Human papillomavirus, Survival analysis

CLC Number:

R366

HOU Lichun ,LIN Lijuan. NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma[J]. PRACTICAL ONCOLOGY JOURNAL, 2016, 30(4): 351-355.

References

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NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma

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