自噬介导的肿瘤相关巨噬细胞调控机制的研究进展

doi:10.11904/j.issn.1002-3070.2018.02.008

Abstract

Abstract: Tumor cells,and a variety of stromal cells,immune cells and cytokines constitute a complex tumor microenvironment.Among them,tumor-associated macrophages(TAMs)are one of the most important stromal cells in microenvironment and actively participate in tumor growth,invasion and metastasis.Autophagic activity not only plays a key role in the cellular stress response and maintaining the stability of the internal environment,but it also is closely associated with tumor,involving in the generation and recruitment of TAMs precursor cells in the tumor microenvironment and the important regulatory steps of polarization of the precursor cells to TAMs.The study of autophagy-mediated control of TAMs is conducive to a more comprehensive understanding of the tumor micro-environment in the complex regulatory network system,and may open a new situation in cancer treatment.

Key words: Autophagy, Tumor associated macrophages, Tumor microenvironment

CLC Number:

R737

ZHANG Pei, CAO Shoubo, YU Yan. Research progress of autophagy-mediated regulation of tumor associated macrophages[J]. PRACTICAL ONCOLOGY JOURNAL, 2018, 32(2): 130-134.

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Research progress of autophagy-mediated regulation of tumor associated macrophages

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