Abstract: Objective The aim of this study was to investigate the expression of CXC chemokine receptor 4(CXCR4)and angiogenic proteins vascular endothelial growth factor(VEGF)in primary testicular lymphoma(PTL),and to analyze the relationship between the expression of CXCR4 and VEGF with CNS invasion and prognosis. Methods Immunohistochemical method was used to detect the expression of CXCR4 and VEGF proteins in 59 PTL tumor tissues and analyze the relationships of CXCR4 and VEGF expression with various clinical pathological features and prognosis. Results Patients with high expression of CXCR4 and VEGF protein were more prone to central nervous system infiltration;The expression of CXCR4 was correlated to the VEGF expression(φ=0.423,P=0.001);The expression of CXCR4 protein were related to Ann Arbor stage,IPI score,serum LDH level,Ki67;The expression of VEGF protein were related to Ann Arbor stage,IPI score,B symptoms,serum LDH level,recurrence,complete remission status;Univariate analysis confirmed that staging,IPI score,B symptoms,serum LDH level,CNS involvement,complete remission status;The expression of CXCR4 and VEGF proteins were significantly related to the patient's PFS and are important factors for poor prognosis. Conclusion Patients with high expression of CXCR4 and VEGF protein have a higher risk of central nervous system invasion.Therefore,they can be used as predictive indicators for patients with high expression to take preventive measures in advance to improve prognosis,and as a potential therapeutic target to provide more options for clinical treatment.

Key words: Primary testicular lymphoma, Central nervous system involvement, CXCR4, VEGF